Du J

BACKGROUND: Endometriosis is a complex gynecological disorder lacking reliable biomarkers. This study aimed to identify core diagnostic genes through integrated computational approaches. Multiple endometriosis transcriptomic datasets were a…

Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and dose-limiting side effect of oxaliplatin treatment, yet its molecular mechanisms remain incompletely understood. Calcitonin gene-related peptide alpha (CGRPα, encoded by Ca…

ObjectiveTo evaluate and compare the efficacy of tubal reanastomosis and in vitro fertilisation in achieving reproductive success in women who had undergone tubal ligation and desired additional children.MethodsThis study included 152 and 9…

Pyroptosis is a lytic form of regulated cell death driven by inflammasome activation and gasdermin-mediated membrane rupture, characterized by robust inflammatory amplification. High-mobility group box 1 (HMGB1), a multifunctional nuclear p…

Miscarriage occurs in approximately 15% of all pregnancies, and recent studies have suggested a potential role of the microbiome. A nested case-control study from the Swedish Maternal Microbiome cohort was conducted, including 34 participan…

PurposeInfants born after assisted reproductive technology (ART) have more adverse health outcomes than spontaneously conceived infants. Evidence on the impact of ART on the offspring's visual system, particularly refractive errors (REs), r…

This study aimed to investigate the pathogenic mechanisms of jaw cysts by screening for differentially expressed proteins in the tissues of patients with jaw cysts using proteomic techniques. Tissue samples were collected from 4 patients wi…

BackgroundThis study aims to investigate the efficacy and safety of dexmedetomidine in treating postoperative acute pain through a clinical randomized controlled trial.MethodsThis study selected 165 patients who underwent general anesthesia…

BACKGROUND: The association between the triglyceride-glucose (TyG) level, its obesity-related derivatives, and the occurrence of endometriosis (EMS) remains ambiguous, particularly in individuals with higher levels of education. This study …

Relative Fat Mass (RFM) is an emerging body fat measurement index that more accurately reflects the distribution of visceral fat. This study aimed to investigate the association between RFM and female infertility. We utilized data from the …

Drug repositioning presents a compelling strategy to accelerate therapeutic development by uncovering new indications for existing compounds. However, current computational methods are often limited in their ability to integrate heterogeneo…

ObjectivesThis study aimed to evaluate a clinical utility of preimplantation genetic testing for aneuploidy (PGT-A) in patients with recurrent pregnancy loss (RPL) and explore a population that benefits from it.MethodsWe analyzed 818 oocyte…

This retrospective cohort study evaluated whether gonadotropin-releasing hormone agonists (GnRHa) used for luteal support during antagonist cycles improved pregnancy outcomes in patients undergoing fresh embryo transfer. We examined 3,115 p…

BACKGROUND: Infertility represents a prevalent condition affecting the reproductive system. It has a global incidence of approximately 17.5%. Nutritional supplements are increasingly used as complementary therapy for female infertility, tho…

Ferredoxins (FDXs) are evolutionarily conserved iron-sulfur (Fe-S) proteins that serve as master regulators of mitochondrial redox homeostasis, governing critical processes including electron transfer, energy metabolism, Fe-S cluster biogen…

BackgroundNei Like DNA Glycosylase 2 (NEIL2) is strongly associated with the risk of Cervical cancer (CC), but the mechanism is not yet clear. Therefore, the aim of this study was to explore the potential mechanisms of NEIL2 as a novel prog…

Uterine corpus endometrial carcinoma (UCEC) is the predominant neoplasm affecting the female reproductive system. Early diagnosis of UCEC is crucial for improving patient survival rates. In this study, we selected and investigated two speci…

Yes-associated protein (YAP) plays a central role in the Hippo pathway, primarily governing cell proliferation, differentiation, and apoptosis. Its significance extends to tumorigenesis and inflammatory conditions, impacting disease initiat…

INTRODUCTION: Endometriosis, a common and distressing gynecological condition, affects fertility and causes pain, is often managed with medications such as Elagolix. The present study aimed to construct a physiologically based pharmacokinet…

BackgroundPelvic floor myofascial pain is one of the pelvic floor dysfunction diseases disturbing women after delivery. There is a lack of objective standardization for the diagnosis of pelvic floor myofascial pain due to the various sympto…

PurposeThe significant global burden of endometrial cancer (EC) and the challenges associated with predicting EC recurrence indicate the need for a dynamic prediction model. This study aimed to propose nomograms based on clinicopathological…

IntroductionThe NLRP3 inflammasome has been implicated in the initiation of inflammation and tumorigenesis; however, its role in epithelial ovarian cancer (EOC) remains unclear.MethodsThis study employed high-throughput sequencing data, ELI…

ObjectiveThe objective of this study was to verify the clinical predictive performance of methylated cysteine dioxygenase type 1 (CDO1m) and CUGBP Elav-like family member 4 (CELF4m) in endometrial cancer (EC) women with postmenopausal bleed…

ObjectiveTo determine whether a reduced dose of follicle-stimulating hormone (FSH) before human chorionic gonadotropin (hCG) trigger during ovarian stimulation can affect in vitro fertilization (IVF) outcomes.MethodsThis study included 347 …