J. McLaren

Chapter 1 1.1 Chapter 1 13.2.2Ce// actf?es/on mo/eci//es Adhesive properties of endometrial cells determine the process of attachment of retrogradely shed endometrium to the peritoneal lining.Several cell adhesion molecules are expressed by…

Endometriosis is the primary cause of female infertility during reproductive age. It is due to the existence of endometrial glands and stromal tissues outside the wall of uterus. The particular prevalence of the disease is still unclear but…

Infertility is defined as a couple's failure to achieve pregnancy after one year of regular, unprotected intercourse. The etiology of infertility can be due to female factors, male factors, combined male and female factors, or have an unkno…

Lead researcher Dr Janet McLaren discusses the results of a new study exploring new concerns that rheumatoid arthritis, lupus, and inflammatory bowel disease may lead to premature ovarian failure and early menopause.

Peritoneal endometriosis is a significant debilitating gynaecological problem of widespread prevalence. It is now generally accepted that the pathogenesis of peritoneal endometriosis involves the implantation of exfoliated endometrium. Esse…

Endometriosis is characterized by an increase in the number, activation and secretory activity of peritoneal fluid macrophages. Factors regulating the activation of these cells may be important in the pathophysiology of this disease. In thi…

Endometriosis, a debilitating disease associated with infertility, is characterized by the prolonged presence of ectopic endometrial tissue and the involvement of activated peritoneal fluid macrophages. Apoptosis, which occurs in both endom…

Angiogenesis is important in the pathophysiology of endometriosis, a condition characterized by implantation of ectopic endometrium in the peritoneal cavity. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor involved i…

Active endometriosis is characterized by hypervascularization both within and surrounding the implant; therefore the presence of angiogenic factors in the peritoneal environment would be of great importance. Vascular endothelial growth fact…

Reproductive Molecular Research Group, Department of Obstetrics and Gynaecology, University of Cambridge, Clinical School, The Rosie Maternity Hospital, Cambridge, United Kingdom. Hum Reprod 1996;11:220-223