Liu B

Endometriosis, affecting approximately 10% of reproductive-aged women worldwide, is widely recognized as a chronic inflammatory disease. Inflammation-related genes (IRGs) play a crucial role in the occurrence and progression of various dise…

BACKGROUND: Effective individualized tools to predict cumulative live birth rates are lacking for patients with ovarian endometriomas undergoing In Vitro Fertilization or Intracytoplasmic Sperm Injection after ultrasound-guided ethanol scle…

Human endometrial receptivity is a critical determinant of pregnancy success; however, in vivo studies of its features and regulation are particularly challenging due to ethical restrictions. Recently, the development of human endometrial a…

BackgroundCervical squamous cell carcinoma (CSCC) exhibits profound spatial heterogeneity in evolutionary trajectories across distinct tumour foci, yet the underlying mechanisms remain poorly understood.MethodsIn this study, we performed an…

OBJECTIVE: This study aims to investigate the efficacy of novel embolic materials in the treatment of adenomyosis via partial embolization of uterine arteries. METHODS: From June 2023 to June 2025, we used gelatin sponge particles, liquid s…

High-throughput sequencing enables efficient processing of DNA and RNA samples in batches, but batch effects can obscure true biological signal. We propose using anticlustering as an automated method to assign samples to balanced batches, m…

High throughput sequencing is a powerful tool for processing large amounts of DNA and RNA samples in batches. Proper experimental design and statistical methods are required to mitigate systematic technical factors due to differences in bat…

BackgroundThe risk of preterm birth (PTB) is associated with maternal hyperglycemia but differs by combinations of abnormal oral glucose tolerance test (OGTT) values. However, the potential pathway by which maternal hyperglycemia affects PT…

Abstract Endometriosis, affecting approximately 10% of reproductive-aged women worldwide, is a typical chronic inflammatory disease. Inflammation-related genes (IRGs) play a crucial role in the occurrence and progression of various disease…

Decreased ovarian reserve (DOR) refers to the decreased ability of the ovaries to produce eggs and the low quality of the follicles, which may lead to abnormal menstruation and infertility. However, the role of circular RNAs (circRNAs) in D…

Endometriosis is an estrogen-dependent chronic inflammatory disease which causes dysmenorrhea, chronic pelvic pain, and infertility in women of childbearing age, significantly impacting their quality of life and physical and mental health. …

Single-cell technologies are expanding our understanding of endometriosis and adenomyosis, which are sister disorders of the uterine endometrium that contain similar complements of lesion cell types but in different locations-outside and in…

IntroductionAlthough advanced paternal age (APA) is increasingly scrutinized in reproductive medicine, its independent impact on embryo development and clinical outcomes remains contentious, particularly when controlling for maternal age an…

Ageing of the endometrium is a critical factor that affects reproductive health, yet its intricate mechanisms remain poorly explored. In this study, we performed transcriptome profiling and experimental verification of endometrium and endom…

Research questionCan machine learning models accurately predict the risk of early miscarriage following single vitrified-warmed blastocyst transfer (SVBT)?DesignA dual-center retrospective analysis of 1,664 SVBT cycles, including 308 early …

ObjectiveTo analyze the relationship and predictive value of Netrin-1 expression and ultrasonic blood flow parameters with the severity of cervical intraepithelial neoplasia (CIN).MethodsA retrospective analysis was performed on 115 patient…

Fibrosis leads to structural damage and functional decline and is characterized by an accumulation of fibrous connective tissue and a reduction in parenchymal cells. Because of its extremely poor prognosis, organ fibrosis poses a significan…

Ovarian tumor (OT) is the most lethal form of gynecologic malignancy, with minimal improvements in patient outcomes over the past several decades. Metastasis is the leading cause of ovarian cancer-related deaths, yet the underlying mechanis…

Endometriosis is an enigmatic disease whose diagnosis and management are being transformed through innovative surgical, molecular, and computational technologies. Integrating single-cell and other omic disease data with clinical and surgica…

BackgroundPhthalate esters (PAEs) are a class of synthetic compounds that are extensively utilized in a range of consumer products, and they significantly affect both environmental conditions and human reproductive health. Especially, many …

Endometriosis is a chronic, estrogen-dependent condition affecting over 190 million women globally, characterized by the ectopic presence of endometrial-like tissue that leads to inflammation, pain, and infertility. Despite its prevalence, …

Through a combination of single-cell/single-nucleus RNA-Seq (sc/snRNA-Seq) data analysis, immunohistochemistry, and primary macrophage studies, we have identified pathogenic macrophages characterized by Tet methylcytosine dioxygenase 3 (TET…

IntroductionThe primary clinical challenge associated with follicular thyroid carcinoma (FTC) lies in accurately diagnosing the condition, particularly in distinguishing it with follicular thyroid adenoma (FTA) due to their overlapping cyto…