Jinghe Lang

OBJECTIVE: To describe the clinical characteristics of patients with Herlyn-Werner-Wunderlich syndrome (HWWS) and explore the relationship between an obstructive genital abnormality and pelvic endometriosis. DESIGN: Case series. SETTING: …

OBJECTIVE: To profile the long noncoding RNA (lncRNA) expression patterns in ovarian ectopic endometrial tissue compared with paired eutopic endometrial tissue. DESIGN: Genome-wide expression analysis of human tissue. SETTING: University …

Endometriosis (EM) impacts the healthcare and the quality of life for women of reproductive age. However, there is no reliable noninvasive diagnosis method for either animal study or clinical use. In this work, a novel imaging method, photo…

OBJECTIVE: To study the significance of pain symptoms and physical signs to diagnosis of deeply infiltrating endometriosis (DIE). METHODS: Totally 500 patients with laparoscopic diagnosis of endometriosis were studied retrospectively and d…

BACKGROUND: Numerous studies have described the association between polymorphisms in the tumor necrosis factor (TNF) gene and risk of endometriosis. However, the results remain controversial. Here we reviewed studies reporting the associati…

BACKGROUND: Laparoscopic surgery in pregnant women has become increasingly more common; however, the safety of laparoscopy in this population has been widely debated in emergent situations and big size at bigger pregnant weeks. This study w…

OBJECTIVE: To analyze the clinical characteristics of patients with Herlyn-Werner-Wunderlich (HWW) syndrome. METHODS: Seventy patients with a confirmed diagnosis of HWW syndrome admitted to the Peking Union Medical College Hospital between…

OBJECTIVE: To investigate the pathogenesis of endometriosis by studying endometriosis coexisting with variable genital tract anomalies and analysis the association between obstructive or non-obstructive anomalies with endometriosis. METHOD…

BACKGROUND: Currently, all the diagnostic indicators for endometriosis lack perfect sensitivity and specificity. According to the characteristic of endometriosis, we analyzed the new biomarker neutrophil-to-lymphocyte ratio (NLR) and the co…

STUDY OBJECTIVE: To investigate whether the combined value of the platelet-lymphocyte ratio (PLR) and serum cancer antigen 125 (CA 125) can be used in diagnosing moderate to severe endometriosis. DESIGN: A retrospective study (Canadian Tas…

Endometriosis, characterized by endometrial-like tissue outside the uterus, is a frequently occurred benign gynecologic disease that afflicts mainly women of reproductive age, with a prevalence of 6% to 10%. Endometriosis can be subdivided …

OBJECTIVE: The issue of female sexual function is often overlooked in women with endometriosis, especially in mainland China. The objectives of this study were to estimate the prevalence and associated factors of female sexual dysfunction i…

OBJECTIVE: To study the relationship between the clinic-pathological features and pain symptoms in patients with endometriotic cyst (EM). METHODS: The medical data of symptoms, laparoscopy and pathology examination in 416 patients with end…

Objectiv e To study the relationship between the clinic-pathological features and pain symptoms in patients with endometriotic cyst (EM). Methods The medical data of symptoms,laparoscopy and pathology examination in 416 patients with…

STUDY OBJECTIVE: To investigate the clinical presentations, diagnosis, treatment modalities and prognosis of endometriosis in adolescents in China. DESIGN: Retrospective study. SETTING: Data were collected from records of the Peking Union…

BACKGROUND: Clear-cell carcinoma transformed from an abdominal wall scar is extremely rare; there are only 22 cases reported in literature. Here we report a case of a patient with clear-cell carcinoma of the abdominal wall after cesarean de…

This paper demonstrates an in vitro model to simulate the microenvironment of endometriosis. We used microfluidic channels with cover slips to pattern and release endometrial stromal cells (ESCs) and human peritoneal mesothelial cells (HPMC…

The etiology and pathogenesis of endometriosis are complex and still incompletely understood. So many theories have been developed

OBJECTIVE: To investigate the expression of transient receptor potential vanilloid subtype 1 (TRPV1) in uterosacral ligament and its correlation with pain in endometriosis. METHODS: Total of 54 patients undergoing endometriotic lesions exc…

Endometriosis has critical implications for women's quality of life. However, an overview of the current knowledge of this issue is limited. The objective of this systematic review was to determine the extent of endometriosis and its treatm…

OBJECTIVE: To investigate the influence of gonadotropin releasing hormone agonist (GnRH-a) on the expression mRNA of nerve growth factor (NGF) and its receptors (TrkA and P75NTR) in normal and eutopic endometrial stromal cells (ESC). METHO…

STUDY QUESTION: Can plasma microRNAs be used as a non-invasive diagnostic test for the detection of endometriosis? SUMMARY ANSWER: Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis compared with those with…

Endometriosis, with a prevalence rate ranging from 6% to 10%, is the major contributor to pelvic pain and subfertility, and considerably reduces the quality of life in affected women. However, the pathogenesis of this disease remains largel…

OBJECTIVE: To study the pathologic characteristics of eutopic endometrium in patients with endometriosis. METHODS: Pathologic characteristics of eutopic endometrium were studied in 176 patients with endometriosis in Peking Union Medical Co…