Marco Reschini

PURPOSE: A reduced fertilization rate is a frustrating condition for patients and embryologists. This study aimed develop a statistical metric, LOW FERTILIZATION, to determine whether a distinct pathological entity underlies reduced fertili…

Neonatal uterine bleeding (NUB) has been hypothesized as a relatively common early-life event potentially linked to the later development of endometriosis through retrograde menstruation. However, its true prevalence and biological nature r…

RESEARCH QUESTION: Can transvaginal ultrasonography (TVUS) reliably detect and quantify free pelvic fluid (FPF) as a surrogate marker of retrograde menstruation, and how do its volume and characteristics vary across menstrual phases, charac…

The link between endometriosis and other medical conditions is gaining attention. Such insights could enhance clinical approaches to manage the disease and potentially reveal new, unrecognized mechanisms of its development. The aim of this …

• X offers insights into public attitudes on FP and opportunities for better discussions. • Information is mainly given by private providers, with limited public institution engagement. • Private institutions’ focus may relate to the contro…

INTRODUCTION: Endometriosis is a common, benign, chronic inflammatory disease with multiple consequences, from chronic pain to systemic comorbidities and poor quality of life. As it usually affects people of reproductive age, one of the mos…

BACKGROUND: In the field of in vitro fertilization (IVF), the search for reliable success predictors is ongoing, with novel biomarkers gaining increasing attention. Epigenetic clocks, mathematical models based on DNA methylation (DNAm) patt…

BACKGROUND: Pregnancy involves a fine-tuned hormonal interplay between the fetus, placenta, and mother, which shapes long-term developmental outcomes. Endometriosis has been hypothesized to originate in utero due to altered fetal exposure t…

Abstract Study question Is IVF more effective than surgery for treating infertility associated to ovarian and deep endometriosis detected at ultrasound? Summary answer The live birth rate within a year from the study’s beginning was signifi…

BACKGROUND: Early reports from the beginning of this century highlighted significant ovarian damage following laparoscopic stripping of endometriomas. During the last 2 decades, the raised awareness of the possible detrimental effects of su…

Abstract Study question Does endometriosis affect the cumulative live birth rate in patients undergoing IVF compared to matched controls? Summary answer The cumulative live birth rates of patients with endometriosis are comparable to those …

Abstract Study question Do umbilical vein cord blood hormonal levels differ among pregnant women with endometriosis, polycystic ovarian syndrome (PCOS), and healthy controls delivering singleton female infants? Summary answer Umbilical cord…

RESEARCH QUESTION: What is the rate of second children among women affected from endometriosis who conceived their first child through Assisted Reproduction Technologies (ARTs)? Are there differences between endometriosis and other causes o…

(Abstracted from Reprod Biomed Online 2023;47:103414 Endometriosis is a well-established risk factor for infertility due to alterations in folliculogenesis, oocyte release from the ovaries, tubal function, and oocyte fertilization. In addit…

PURPOSE: There is several albeit not univocal evidence suggesting that ovarian reserve is not related to the chance of natural pregnancy, provided that the remnant follicular pool is sufficient to ensure regular menstrual cycles. Neverthele…

Abstract Study question Are women with endometriosis in a state of systemic imbalance between pro- and anti-coagulants? Summary answer Women with endometriosis do not seem to exhibit a coagulation imbalance, at least at a systemic level. Wh…

PurposeTo understand how often couples return to ART centres for a second child.MethodsRetrospective monocentric cohort study including women who had a first live birth with IVF. The primary objective was to assess the rate of those returni…

PURPOSE: A reduced oocyte competence has been claimed as one of the factors underlying infertility in women with endometriosis. This idea has justified the hypothesis that intracytoplasmic sperm injection (ICSI), rather than conventional IV…

The modality of endometrial preparation for the transfer of frozen-thawed embryos may influence maternal and fetal adaptation to pregnancy and could thus impact the results of the first trimester combined screening test. We conducted a retr…

RESEARCH QUESTION: Is endometriosis detrimental to embryo implantation? DESIGN: A retrospective matched case-control study of women with a surgical or ultrasound diagnosis of endometriosis at Fondazione IRCCS Ca'Granda Ospedale Maggiore Po…

The second-to-four digit ratio (2D:4D) has been proposed as a marker of prenatal hormonal exposure. It is suggested that prenatal exposure to androgens results in a shorter 2D:4D ratio, whereas a prenatal oestrogenic environment results in …

Study questionDo low levels of anti-Müllerian hormone (AMH) or antral follicle count (AFC) properly predict miscarriage in young women conceiving with ART?Summary answerLow ovarian reserve, as indicated by AMH or AFC, is not associated with…

Abstract Study question Does endometriosis affect endometrial receptivity in frozen/thawed embryo transfer (FET) cycles? Summary answer Stage III/IV endometriosis-patients undergoing ART submitted to FET cycles have implantation, pregnancy …