Donnez J

The diagnosis of peritoneal endometriosis at the time of laparoscopy is often made by the observation of typically puckered black or bluish lesions. There are also numerous subtle appearances of peritoneal endometriosis. The lesions are fre…

ObjectiveTo evaluate the ovarian response to stimulation for IVF in endometriosis patients who have previously undergone laparoscopic treatment of peritoneal and/or ovarian endometriosis (CO2 laser vaporization).Patients and methodsRetrospe…

This manuscript is a review of new ideas regarding the pathogenesis of peritoneal endometriosis, ovarian endometriosis, and retroperitoneal adenomyosis. Peritoneal endometriosis, the different aspects of which (black, red and white) represe…

This manuscript discusses the diagnosis and imaging of adenomyotic disease of the retroperitoneal space, a pathology that we have defined as retroperitoneal adenomyotic disease (RAD). By prospective analysis, comparing barium enema, magneti…

ObjectiveTo compare the efficacy of Dienogest versus Decapeptyl at 3.75 mg as consolidation therapy for surgery in the treatment of endometriosis.DesignMulticenter, open, randomized, parallel-group clinical trial.SettingVolunteer patients i…

ObjectiveTo examine the possible involvement of iron in the physiopathology of endometriosis.DesignProspective study.SettingDepartment of gynecology in a university hospital.Patient(s)Seventy patients undergoing laparoscopy.Intervention(s)C…

ObjectiveTo review the literature associating pelvic endometriosis with oxidative stress and to discuss the potential causes and consequences of a pro-oxidant environment in the peritoneal cavity.DesignLiterature survey.Result(s)Several stu…

ObjectiveTo test whether hemoglobin may accumulate in the peritoneal cavity in case of endometriosis and to assess whether heme oxygenases (HO), detoxifying heme, are expressed in ectopic endometrium and peritoneal cells.DesignProspective s…

This article is a review of the efficacy of medical and surgical treatment of endometriosis-associated infertility and pelvic pain. Endometriosis is the cause of pelvic pain (dysmenorrhea, dyspareunia) and infertility in more than 35% of wo…

This review discusses the efcacy of a combined, medical (GnRH agonist) and surgical, therapy in endometriosisassociated infertility. Because of the limited information currently available on the activity of lesions in minimal and mild endom…

OBJECTIVE: To present data from 18 cases of ureteral endometriosis. DESIGN: Prospective clinical study. SETTING: Department of gynecology at a university hospital. PATIENT(S): Four hundred and five patients with severe dysmenorrhea or de…

ObjectiveTo evaluate the ovarian response to stimulation conducted for IVF treatment in women who have undergone conservative surgery for endometriomas.DesignRetrospective study with prospective selection of participants and controls.Settin…

OBJECTIVE: To present data from a series of 17 cases of bladder endometriosis. DESIGN: Clinical study. SETTING: A university hospital department of gynecology. PATIENT(S): Seventeen patients complaining of menstrual urinary symptoms and/…

ObjectiveTo evaluate the implantation of menstrual endometrium and the early stages of evolution of endometriotic lesions.DesignExperimental prospective study.SettingAn academic research environment.AnimalsTen nude mice.Intervention(s)A min…

OBJECTIVE: To provide an overview of the medical, surgical and combined therapy options for endometriosis. RESULTS: Available medical options include danazol, progestogens, gestrinone, oral contraceptive agents, analgesics and gonadotropin-…

Angiogenesis is likely to be involved in the pathogenesis of endometriosis. According to the transplantation theory, when the exfoliated endometrium is attached to the peritoneal layer, the establishment of a new blood supply is essential f…

ObjectiveTo determine whether interstitial collagenase (matrix metalloproteinase-1), known to play a pivotal role in the initiation of menstruation, contributes to the pathogenesis of endometriosis.DesignSerial sections of peritoneal red an…

ObjectiveTo assess the proliferative activity of eutopic and ectopic endometrium throughout the menstrual cycle and its correlation to steroid receptor content.DesignThe immunohistochemical use of Ki 67 was applied to investigate the prolif…

OBJECTIVE: To compare the localization of adhesion proteins (laminin and fibronectin) and their receptors of the integrin family in endometriosis and endometrium. DESIGN: An immunohistochemical study. SETTING: University Hospital, Departm…

ObjectiveTo review the histogenesis of peritoneal, ovarian, and rectovaginal endometriotic lesions.DesignThe comparison of morphologic, morphometric, and histochemical data observed in each type of lesion.SettingA university hospital depart…

OBJECTIVE: Laparoscopic procedure with excision of deep fibrotic endometriotic nodules of the rectovaginal septum and histological study of the lesions. SETTING: An academic teaching hospital. PARTICIPANTS: A series of 500 women undergoing …