Sisse Rye Ostrowski

No ORCID on file · 9 papers in corpus · active 2021-2026

Study types

  • article 1
  • meta-analysis 1
  • preprint 1

Condition tags

  • endometriosis 3
  • infertility 1
2026
Genetic liability for endometriosis associates with pain, inflammatory, and metabolic traits: a polygenic score analysis
·doi:10.64898/2026.06.18.26355987

Purpose Endometriosis is associated with pain, cardiometabolic, psychiatric, and immune comorbidities. We tested whether the genetic liability captured by an endometriosis polygenic risk score (PRS) extends to these comorbidities through s…

2025
Characterization of small extracellular vesicles from ovarian cancer patients and pre-diagnostic patient samples: Evidence from the Danish blood donor study.
PloS one ·doi:10.1371/journal.pone.0323529

AimOvarian cancer (OC) is the leading cause of gynecological cancer deaths. Current biomarkers of OC are not specific or sensitive enough. Extracellular vesicles (EVs), EV surface proteins and their cargo microRNA (miRNA) show potential as …

meta-analysis 2025
Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum
Nature genetics ·doi:10.1038/s41588-025-02156-8

Genome-wide association studies (GWASs) may help inform the etiology of infertility. Here, we perform GWAS meta-analyses across seven cohorts in up to 42,629 cases and 740,619 controls and identify 25 genetic risk loci for male and female i…

preprint 2025
The burden of endometriosis on quality of life in Danish blood donors
·doi:10.21203/rs.3.rs-6620337/v1

Abstract Background: Endometriosis is a complex condition with a wide range of comorbidities. It is widely underdiagnosed, with a diagnostic delay of 4 to 10 years, potentially leading to worsened disease progression and a higher burden of…

article 2025
The burden of endometriosis on quality of life in Danish women: an analysis of the Danish Blood Donor Study
BMC medicine ·doi:10.1186/s12916-025-04398-z

BACKGROUND: Endometriosis is a complex condition with a wide range of comorbidities. It is widely underdiagnosed, with a diagnostic delay of 4 to 10 years, potentially leading to worsened disease progression and a higher burden of comorbidi…

2024
Genome-wide association meta-analysis identifies five loci associated with postpartum hemorrhage.
Nature genetics ·doi:10.1038/s41588-024-01839-y

Bleeding in early pregnancy and postpartum hemorrhage (PPH) bear substantial risks, with the former closely associated with pregnancy loss and the latter being the foremost cause of maternal death, underscoring the severe impact on maternal…

2023
Cohort Profile: The Danish Blood Donor Study.
International journal of epidemiology ·doi:10.1093/ije/dyac194
2023
Genetic effects on the timing of parturition and links to fetal birth weight.
Nature genetics ·doi:10.1038/s41588-023-01343-9

The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n = 195,555), identifying 22 associate…

2021
Cytokine autoantibodies are stable throughout the haematopoietic stem cell transplantation course and are associated with distinct biomarker and blood cell profiles.
Scientific reports ·doi:10.1038/s41598-021-01952-6

Cytokine-specific autoantibodies (c-aAbs) represent an emerging field in endogenous immunodeficiencies, and the immunomodulatory potential of c-aAbs is now well documented. Here, we investigated the hypothesis that c-aAbs affects inflammato…