Zhang F

BackgroundThis study systematically investigated phenotypes causally associated with Alzheimer's disease (AD) across the phenome and validated the findings at cognitive and neuroimaging levels using real-world clinical data.MethodsWe perfor…

Catalpol, an iridoid glycoside predominantly derived from the fresh or dried root tuber of Rehmannia glutinosa Libosch (a member of the Scrophulariaceae family), it is a representative compound with the highest content in Rehmannia glutinos…

Currently available classification criteria for obstetric antiphospholipid syndrome (OAPS) are often overly strict and may miss a considerable number of patients with so-called "non-criteria-defined OAPS". We aimed to establish a diagnostic…

BackgroundPericentric inversion of chromosome 9 [inv (9)] is a common chromosomal polymorphism found in approximately 1-2% of the population. While inv(9) has been generally considered a benign variant, its potential effects on reproductive…

Emerging evidence suggests that the gut microbiota plays a crucial role in endometriosis (Endo) and inflammatory bowel disease (IBD). This study aimed to explore gut microbial signatures in women with either or both conditions, compared to …

Ovarian senescence is accompanied by inflammatory responses, yet the underlying mechanism remains incompletely elucidated. In this study, transcriptome sequencing was performed on ovarian granulosa cells from advanced-age patients and norma…

BackgroundPelvic floor surface electromyography (sEMG) is widely used to evaluate and treat pelvic floor dysfunctions (PFDs). Based on sEMG, the Glazer protocol was developed over 20 years ago with a limited sample size, making it challengi…

Uterine Corpus Endometrial Carcinoma (UCEC) represents a common malignant neoplasm in women, with its prognosis being intricately associated with available therapeutic interventions. In the past few decades, there has been a burgeoning inte…

BACKGROUND: Endometriosis (EM) is a chronic gynecological disorder characterized by the growth of endometrial-like tissue outside the uterus, leading to pain and infertility. Recent studies suggest that antioxidants may play a protective ro…

BackgroundEndometrial thickness (EMT) is a crucial indicator of endometrial receptivity in assisted reproductive technology (ART). However, its relationship with pregnancy outcomes remains unclear, especially across different cycle types su…

DisignThis is a cross-sectional study.ObjectivesThis study aimed to identify the risk factors associated with body image disturbances in patients with polycystic ovary syndrome (PCOS).MethodsThis study included married women diagnosed with …

PurposePolycystic ovary syndrome (PCOS) is an endocrine syndrome that afflicts women of childbearing age, whose specific pathogenesis is unknown. Combined multiomics analysis on it is still lacking. The purpose of this study was to use comb…

PurposeIn vitro fertilization and embryo transfer (IVF-ET) has become crucial for infertile couples. Previous studies have suggested that multiple ETs are associated with increased risks of preterm birth and low birth weight. The current st…

Diabetic kidney disease (DKD) is recognized as one of the leading causes of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) worldwide, representing a rapidly growing global public health concern. Despite significant advance…

BackgroundThe Coronavirus disease 2019 (COVID-19) pandemic has significantly impacted global health and shares several clinical features with ulcerative colitis (UC). However, the existence of a common pathological mechanism between COVID-1…

ObjectiveTo investigate the benefits of menstrual management in women undergoing hematopoietic stem cell transplantation (HSCT), in whom heavy menstrual bleeding (HMB) can be an underestimated bleeding complication.MethodsThis was a retrosp…

BackgroundThis study investigated the safety and efficacy of hysteroscopic sutureless fixation of the levonorgestrel-releasing intrauterine system (LNG-IUS) for treating heavy menstrual bleeding (HMB), providing a viable therapeutic option …

AimTo investigate the risk factors associated with postpartum urinary retention after cesarean section (CS) and to determine the associated morbidity rate.MethodsThis study was a population-based retrospective case-control study analyzed us…

Retroperitoneal squamous cell carcinoma (SCC) is an extremely rare tumor originating from the retroperitoneum, with an unclear etiology and origin. Imaging studies are the preferred diagnostic modality for retroperitoneal tumors. The presen…

JOURNAL/nrgr/04.03/01300535-202503000-00032/figure1/v/2024-06-17T092413Z/r/image-tiff Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Sal) is a catechol isoquinoline that causes neurotoxicity and shares structural similar…

Abstract Background :To analyze the prevalence and burden of disease (Disability-Adjusted Life Years) of endometriosis in 204 countries and regions from 1990 to 2021, and evaluate its global trends, regional differences and association …

ObjectiveTo investigate the associations between triglyceride glucose-body mass index (TyG-BMI) and reproductive outcomes in women with polycystic ovary syndrome (PCOS) undergoing frozen embryo transfer (FET).MethodsThis retrospective cohor…

OBJECTIVE: The aim of this study is to assess the use of machine learning methodologies in the diagnosis of endometriosis (EM). METHODS: This study included a total of 106 patients with EM and 203 patients with non-EM conditions (like simp…

PurposeTo investigate the relationship between blood lead levels (BLLs) and IVF clinical outcomes in infertile females and to further explore the possible involvement of granulosa cell (GC) endoplasmic reticulum (ER) stress in the process.M…

BACKGROUND: Gynecological disorders are a wide range of health problems affecting the female reproductive system, which poses substantial health challenges worldwide. Increasing number of observational studies have associated mood instabili…