Pauliina Damdimopoulou

No ORCID on file · 8 papers in corpus · active 2010-2025

Study types

  • article 2
  • review 1

Condition tags

  • endometriosis 1
  • adenomyosis 1
2025
Epidemiologically relevant phthalate mixture and mono(2-ethyl-5-hydroxyhexyl) phthalate exposure alter cell energy metabolism in primary mouse granulosa cells.
Reproductive toxicology (Elmsford, N.Y.) ·doi:10.1016/j.reprotox.2025.108938

Many products including plastic food containers, medical tubing, and personal care products contain phthalate diesters. Phthalates have been shown to negatively affect the female reproductive system. However, the ovarian cellular impacts of…

review 2025
The adult ovary at single cell resolution: an expert review
American journal of obstetrics and gynecology ·doi:10.1016/j.ajog.2024.05.046

The ovaries play a crucial role in both the endocrine health and fertility of adult women. The fundamental functional units of the ovaries, primordial follicles, form during fetal development and constitute the ovarian reserve. Ovaries age …

2022
Endocrine disrupting chemicals interfere with decidualization of human primary endometrial stromal cells in vitro.
Frontiers in endocrinology ·doi:10.3389/fendo.2022.903505

Multiple studies have shown associations between exposure to endocrine disrupting chemicals (EDCs) and reduced fertility in women. However, little is known about the target organs of chemical disruption of female fertility. Here, we focus o…

article 2022
Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice
International journal of molecular sciences ·doi:10.3390/ijms23094815

Hydroxysteroid (17beta) dehydrogenase type 1 (HSD17B1) is an enzyme that converts estrone to estradiol, while adenomyosis is an estrogen-dependent disease with poorly understood pathophysiology. In the present study, we show that mice unive…

2020
Persistent environmental endocrine-disrupting chemicals in ovarian follicular fluid and in vitro fertilization treatment outcome in women.
Upsala journal of medical sciences ·doi:10.1080/03009734.2020.1727073

Several international organizations have recently highlighted endocrine-disrupting chemicals (EDCs) as factors of concern in human reproduction. Since successful reproduction is dependent on timely and appropriate action of hormones, disrup…

2020
Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals.
Archives of toxicology ·doi:10.1007/s00204-020-02834-y

Modern living challenges female reproductive health. We are witnessing a rise in reproductive disorders and drop in birth rates across the world. The reasons for these manifestations are multifaceted and most likely include continuous expos…

2020
Safeguarding Female Reproductive Health against Endocrine Disrupting Chemicals-The FREIA Project.
International journal of molecular sciences ·doi:10.3390/ijms21093215

Currently available test methods are not well-suited for the identification of chemicals that disturb hormonal processes involved in female reproductive development and function. This renders women's reproductive health at increasing risk g…

article 2010
Novel Hydroxysteroid (17β) Dehydrogenase 1 Inhibitors Reverse Estrogen-Induced Endometrial Hyperplasia in Transgenic Mice
The American Journal of Pathology ·doi:10.2353/ajpath.2010.090325

Local estrogen production plays a key role in proliferative endometrial disorders, such as endometrial hyperplasia and cancer. Hydroxysteroid (17beta) dehydrogenase 1 (HSD17B1) is an enzyme that catalyzes with high efficiency the conversion…