Gjorgoska M

No ORCID on file · 6 papers in corpus · active 2021-2026

Study types

  • article 1
  • other 1

Condition tags

  • endometriosis 2
2026
Targeting Steroid-Metabolizing Enzymes with 15β-Substituted Estrone Analogues: Dual Discovery of AKR1C2/17β-HSD1 Inhibitors and a Fluorescent 17β-HSD1 Ligand
Cancers
2025
A novel serum-based steroid-protein panels for differentiating ovarian cancer from non-malignant adnexal masses.
Cancer cell international ·doi:10.1186/s12935-025-04047-8

BackgroundOvarian cancer is the deadliest gynecological malignancy, largely due to the advanced stage at diagnosis in most patients. This study investigates whether systemic steroids can serve as biomarkers to distinguish malignant ovarian …

2024
Steroid sulfatase and sulfotransferases in the estrogen and androgen action of gynecological cancers: current status and perspectives.
Essays in biochemistry ·doi:10.1042/ebc20230096

Sulfatase (STS) and sulfotransferases (SULT) have important role in the biosynthesis and action of steroid hormones. STS catalyzes the hydrolysis of estrone-sulfate (E1-S) and dehydroepiandrosterone-sulfate (DHEA-S), while sulfotransferases…

article 2024
The effect of androgens on the risk of endometriosis sub-phenotypes and ovarian neoplasms: A Mendelian randomization study
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2024.106482

Endometriosis is a complex gynecological pathology with a broad spectrum of symptoms, affecting around 10% of reproductive-aged women. Ovarian cancer (OC) is a heterogeneous disease for which we lack effective diagnostic and therapeutic str…

other 2023
17β-Hydroxysteroid dehydrogenases types 1 and 2: Enzymatic assays based on radiometric and mass-spectrometric detection
Methods in enzymology ·doi:10.1016/bs.mie.2023.04.015

The 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) has a key role in estrogen biosynthesis as it catalyzes the reduction of estrone to the most potent estrogen, estradiol. Estradiol has a high affinity for estrogen receptors and thus sti…

2021
Estrogens and the Schrödinger's Cat in the Ovarian Tumor Microenvironment.
Cancers ·doi:10.3390/cancers13195011

Ovarian cancer is a heterogeneous disease affecting the aging ovary, in concert with a complex network of cells and signals, together representing the ovarian tumor microenvironment. As in the "Schrödinger's cat" thought experiment, the con…