Xiaoshan Chai

No ORCID on file · 9 papers in corpus · active 2021-2026

Study types

  • article 6
  • other 2
  • preprint 1

Condition tags

  • endometriosis 9
other 2026
Identification of a Potential Biomarker PDGFRA for Endometriosis Based on Comprehensive Analysis of Multiple Omics Data
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-025-02049-5

Endometriosis (EMs) is a common chronic inflammatory gynecological disorder. But the exact pathogenetic mechanism of the disease is not clear, with some theories proposing that the disease is caused by the interaction of endocrine, immune, …

article 2025
PDPK1 governs macrophage M2 polarization via hypoxia-driven CD47/AKT-glycolytic Axis in endometriosis
Cellular signalling ·doi:10.1016/j.cellsig.2025.111922
article 2025
RND3 Inhibits Endometriosis Progression by Regulating Autophagy and Oxidative Stress Through PLEKHG5
FASEB journal : official publication of the Federation of American Societies for Experimental Biology ·doi:10.1096/fj.202501521rr

Endometriosis (EMS) is a chronic gynecological disease. RND3 is recognized as a potential autophagy-related biomarker in EMS. The aim of this study was to investigate the regulatory role of RND3 on autophagy and oxidative stress in EMS. Imm…

article 2025
Uterine-derived exosomes induce the M2 polarization of macrophages via miR-210-3p/ATP5D to promote endometriosis progression
Life sciences ·doi:10.1016/j.lfs.2025.123383

AIMS: Endometriosis development is associated with peritoneal immune microenvironment abnormality; however, the specific mechanism is uncertain. We aimed to investigate the effects and underlying mechanisms of uterine cavity-derived exosome…

preprint 2023
Uterine-derived exosomes induce the M2 polarization of macrophages via miR210-3p to promote the development of endometriosis
·doi:10.21203/rs.3.rs-3030329/v1

Abstract Background Endometriosis development is associated with peritoneal immune microenvironment abnormality. However, the specific mechanism is uncertain. Investigating peritoneal immune microenvironment regulation mechanisms could intr…

article 2022
Bioinformatical analysis of the key differentially expressed genes and associations with immune cell infiltration in development of endometriosis
BMC genomic data ·doi:10.1186/s12863-022-01036-y

Abstract Background This study explored the key genes related to immune cell infiltration in endometriosis. Results The Gene Expression Omnibus (GEO) datasets (GSE7305, GSE7307, and GSE11691), containing a total of 37 endometriosis and 42 n…

article 2022
Exosomes from the Uterine Cavity Mediate Immune Dysregulation via Inhibiting the JNK Signal Pathway in Endometriosis
Biomedicines ·doi:10.3390/biomedicines10123110

Endometriosis is a chronic inflammatory disease with an uncertain pathogenesis. Peritoneal immune dysregulation plays an important role in the pathogenesis of endometriosis. Exosomes are messengers of intercellular communication. This study…

other 2022
The colonized microbiota composition in the peritoneal fluid in women with endometriosis
Archives of gynecology and obstetrics ·doi:10.1007/s00404-021-06338-7

PURPOSE: The imbalance of microbiome in vivo is believed to be involved in the pathogenicity of endometriosis. This study aimed to investigate and analyze the composition of bacterial communities in the peritoneal fluid of women with endome…

article 2021
Protein arginine methyltransferase 5 mediates THP‑1‑derived macrophage activation dependent on NF‑κB in endometriosis
Experimental and therapeutic medicine ·doi:10.3892/etm.2021.10436

Macrophage-induced inflammation is a major factor in the pathogenesis of endometriosis. The underlying mechanisms, however, remain largely unknown. TNF-α, IL-6, IL-10 and C-C motif chemokine 20 (CCL20) levels in endometrial extracts were de…