Peter C K Leung

No ORCID on file · 17 papers in corpus · active 1981-2025

Study types

  • article 11
  • review 4
  • other 2

Condition tags

  • endometriosis 11
  • infertility 3
  • endometrioma 2
review 2025
RNA modifications in female reproductive physiology and disease: emerging roles and clinical implications
Human reproduction update ·doi:10.1093/humupd/dmaf005

BACKGROUND: RNA modifications, collectively known as the epitranscriptome, represent the third layer of gene regulation, influencing gene expression at transcriptional, post-transcriptional, and translational levels. RNA-modifying proteins …

review 2023
Roles of bone morphogenetic proteins in endometrial remodeling during the human menstrual cycle and pregnancy
Human reproduction update ·doi:10.1093/humupd/dmad031

BACKGROUND: During the human menstrual cycle and pregnancy, the endometrium undergoes a series of dynamic remodeling processes to adapt to physiological changes. Insufficient endometrial remodeling, characterized by inadequate endometrial p…

other 2020
Epidermal growth factor promotes stromal cells migration and invasion via up-regulation of hyaluronate synthase 2 and hyaluronan in endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2020.05.005

OBJECTIVE: To investigate the role(s) of hyaluronan synthase 2 (HAS2) and hyaluronan in disease progression of endometriosis and epidermal growth factor (EGF)-induced motility changes of endometriotic cells. DESIGN: A case-control experime…

article 2020
TGF-β1 induces VEGF expression in human granulosa-lutein cells: a potential mechanism for the pathogenesis of ovarian hyperstimulation syndrome
·doi:10.1038/s12276-020-0396-y

Ovarian hyperstimulation syndrome (OHSS) is one of the most serious and iatrogenic complications that can occur during in vitro fertilization treatment. Although the pathogenesis of OHSS is not fully understood, vascular endothelial growth …

review 2019
Neurotrophins and glial cell line-derived neurotrophic factor in the ovary: physiological and pathophysiological implications
Human reproduction update ·doi:10.1093/humupd/dmy047

BACKGROUND: Neurotrophins [nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4)] and glial cell line-derived neurotrophic factor (GDNF) are soluble polypeptide growth factors …

article 2018
Bone morphogenetic protein 2 increases lysyl oxidase activity via up-regulation of snail in human granulosa-lutein cells
·doi:10.1016/j.cellsig.2018.10.009
article 2017
HOXB4 Immunoreactivity in Endometrial Tissues From Women With or Without Endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719117732164
article 2017
Lithium chloride inhibits StAR and progesterone production through GSK-3β and ERK1/2 signaling pathways in human granulosa-lutein cells
·doi:10.1016/j.mce.2017.08.018
article 2016
ORIGINAL RESEARCH

Leptin receptor is induced in endometriosis and leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways

article 2016
Up-regulated hyaluronan synthase 2 mediates epidermal growth factor-induced cell migration and invasion in human endometriotic stromal cells
·doi:10.1016/j.fertnstert.2016.07.797
article 2015
GDF-8 decreases star expression through ALK5-mediated SMAD3 and ERK1/2 signaling pathways in human granulosa cells
·doi:10.1016/j.fertnstert.2015.07.330
article 2012
Leptin receptor is induced in endometriosis and leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways
Molecular human reproduction ·doi:10.1093/molehr/gas055

Leptin acts as a potential growth stimulator in several normal and neoplastic cells. Recent studies have shown the presence of increased levels of leptin in the peritoneal fluid of patients with endometriosis, implicating leptin in the path…

other 2011
Identification of estrogen response element in the aquaporin-2 gene that mediates estrogen-induced cell migration and invasion in human endometrial carcinoma
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2011-0426

BACKGROUND: Accumulating evidence suggests that aquaporins (AQP) can facilitate cell migration, invasion, and proliferation in tumor development in addition to water transport. OBJECTIVE: The aim of this study was to examine AQP2 expressio…

article 2010
Session 17: Endometrial Biology in Endometriosis and Implantation
·doi:10.1093/humrep/de.25.s1.17
review 2003
Gonadotropin-releasing hormone and reproductive medicine
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC ·doi:10.1016/s1701-2163(16)30206-7

The hypothalamic gonadotropin-releasing hormone (GnRH) is a key regulator of the reproductive system, mainly through its effects on pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release. Gonadotropin-releasing ho…

article 1986
Relationship of gonadotropin-releasing hormone, danazol, and prostaglandin blockade to ovarian enlargement and ascites formation of the ovarian hyperstimulation syndrome in the rabbit
·doi:10.1016/0002-9378(86)90778-7
article 1981
Prostaglandin F in human endometriotic tissue
American Journal of Obstetrics and Gynecology ·doi:10.1016/s0002-9378(16)32641-2