Hiroshi Tamura

Melatonin is a promising reagent that can improve assisted reproductive technology (ART) outcomes in infertility patients. However, melatonin is not effective for all infertile patients, and it remains unclear for which patients melatonin w…

PurposeWe investigate the relationships between oocyte developmental capacity and follicular size of its origin in Japanese women: those undergoing conventional IVF (cIVF) and ICSI, respectively.MethodsA total of 3377 follicles were punctur…

PURPOSE: To identify the upstream regulators (URs) involved in the onset and pathogenesis of ovarian endometrioma. METHODS: Recently, a method called Significance-based Modules Integrating the Transcriptome and Epigenome (SMITE) that uses t…

BACKGROUND: In ovarian endometriomas (OE), the expression statuses of various steroid hormone receptors are altered compared with their expression statuses in eutopic endometrium (EE). For example, in OE, the expressions of estrogen recepto…

BACKGROUND: Endometriosis is considered to be the most intractable cause of female infertility. Administering any type of treatment for endometriosis before in vitro fertilization and embryo transfer (IVF-ET) is an important strategy for im…

Aim: A multicenter, retrospective survey was conducted in order to investigate the current clinical status of adenomyosis in Japan. Methods: The questionnaires covered the management of infertile women with adenomyosis and the outcomes of i…

Purpose: To investigate the impact of adenomyosis on the complications and outcomes of pregnancy in Japan. Methods: We carried out a multicenter retrospective questionnaire survey. A questionnaire regarding pregnancy complications and the o…

Background: Despite endometriosis is common estrogen dependent disease afflicting women in reproductive age, the pathogenesis has not been fully elucidated. Retinoic acid has various functions in cells as biologic modulator, and aberrant re…

BACKGROUND: Despite endometriosis is common estrogen dependent disease afflicting women in reproductive age, the pathogenesis has not been fully elucidated. Retinoic acid has various functions in cells as biologic modulator, and aberrant re…

Additional treatment with a gonadotropin-releasing hormone (GnRH) agonist (GnRHa) before IVF-ET (ultralong GnRHa therapy) has been reported to improve the outcome of IVF-ET in endometriosis patients. However, the mechanism of ultralong GnRH…

BACKGROUND: Additional treatment with a gonadotropin-releasing hormone (GnRH) agonist (GnRHa) before IVF-ET (ultralong GnRHa therapy) has been reported to improve the outcome of IVF-ET in endometriosis patients. However, the mechanism of ul…

Patients and Methods: Endometrial tissues were collected from women with regular menstrual cycles; tissues were used for recovery of primary ESC or RNA extraction or were fixed for immunohistochemistry. Primary ESC were decidualized in vitr…

ObjectiveTo examine whether thin endometria can be improved by increasing uterine radial artery (uRA) blood flow.DesignA prospective observational study.SettingUniversity hospital and city general hospital.Patient(s)Sixty-one patients with …

OBJECTIVE: To summarize the role of melatonin in the physiology and pathophysiology of the ovary. DESIGN: Review of literature. SETTING: University Health Science Center. RESULT(S): Melatonin plays an essential role in the pathogenesis o…

ObjectiveTo characterize pathophysiologic features of a "thin" endometrium.DesignA prospective observational study.SettingUniversity Hospital and City General Hospital.Patient(s)Patients with normal-thickness endometrium (Normal-Em group: e…