Patrick Imesch

Class I histone deacetylases (HDACs-1-3) play an important role in steroid hormone-dependent gene expression and in modulating cell survival and proliferation. We analyzed their expression in a tissue microarray including 74 endometriosis s…

Abstract: Endometriosis is a common gynecological disease affecting 6%–10 % of women of reproductive age and is characterized by the presence of endometrial-like tissue in localizations outside of the uterine cavity as, e.g., endometriotic …

BACKGROUND: The G protein-coupled estrogen receptor (GPER) is thought to be involved in non-genomic estrogen responses as well as processes such as cell proliferation and migration. In this study, we analyzed GPER expression patterns from e…

Mutations of the tumor-suppressor gene ARID1A result in the loss of protein expression of the BRG-associated factor 250a (BAF250a), a large subunit of transcription-regulating Human SWI/SNF complexes, which have an important role in the con…

Endometriose, definiert als das Vorhandensein und Proliferieren von endometriumartigem Gewebe ausserhalb des Cavum uteri, ist eine häufige Ursache für chronische Unterbauchschmerzen, Dysmenorrhö und Sterilität. Insbesondere die medikamentös…

Endometriose, definiert als das Vorhandensein und Proliferieren von endometriumartigem Gewebe ausserhalb des Cavum uteri, ist eine häufige Ursache für chronische Unterbauchschmerzen, Dys menorrhö und Sterilität. Insbesondere die medikamentö…

Endometriose ist eine facettenreiche Erkrankung an der weltweit ungefähr 176 Mio. Frauen leiden. Die Erkrankung definiert sich durch das Vorhandensein und Proliferieren von endometriumartigem Gewebe ausserhalb Cavum uteri, wobei die Ätiopat…

BACKGROUND/AIMS: Endometriosis is a benign but chronic disorder associated with pelvic pain and infertility. Enhanced proliferation and reduced apoptosis susceptibility are characteristics of endometriosis. Cordycepin is a poly(A) polymeras…

OBJECTIVE: To investigate whether the histone deacetylase (HDAC) inhibitor romidepsin down-regulates VEGF (vascular endothelial growth factor) gene expression and abrogates VEGF protein secretion in human epithelial endometriotic cells. DE…

BACKGROUND: Endometriosis is still a highly underdiagnosed disease, and the current medical and surgical treatment of endometriosis is associated with a high recurrence rate. This study investigates the use of derivatives of the human antib…

Romidepsin inhibited HDAC activity, produced acetylation of the histone proteins, up-regulated p21, and down-regulated cyclins B1 and D1, resulting in proliferation inhibition and apoptosis activation in 11z immortalized epithelial endometr…

Despite of several therapeutic options in the treatment of endometriosis, most of them are symptomatically oriented. Histone deacetylase-inhibitors (HDACi) are a novel class of epigenetic acting drugs that inhibit growth and induce apoptosi…