Romidepsin reduces histone deacetylase activity, induces acetylation of histones, inhibits proliferation, and activates apoptosis in immortalized epithelial endometriotic cells

Patrick Imesch, Daniel Fink, André Fedier
Fertility and sterility · 2010 · doi:10.1016/j.fertnstert.2010.04.052 · PMID:20605144
other OA: bronze public-domain-us ⤵ 1 in-corpus citation
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Abstract

Romidepsin inhibited HDAC activity, produced acetylation of the histone proteins, up-regulated p21, and down-regulated cyclins B1 and D1, resulting in proliferation inhibition and apoptosis activation in 11z immortalized epithelial endometriotic cells. Our findings provide evidence that endometriotic cells are sensitive to the epigenetic effects of romidepsin and suggest that endometriosis may be therapeutically targeted by romidepsin.

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Condition tags

endometriosis

MeSH descriptors

Apoptosis Cell Proliferation Depsipeptides Endometriosis Epithelial Cells Histone Deacetylases Histones Peritoneal Diseases Acetylation Acetylation Antibiotics, Antineoplastic Antibiotics, Antineoplastic Apoptosis Cell Line, Transformed Cell Proliferation Depsipeptides Down-Regulation Down-Regulation Drug Evaluation, Preclinical Endometriosis

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europepmc
last seen: 2026-06-11T06:19:48.454388+00:00
pubmed
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License: public-domain-us · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine