André Fedier
ORCID: 0000-0002-5613-8629
· 10 papers in corpus
2014
Vulvar melanoma is the second most common vulvar cancer. Patients with vulvar melanoma usually present with the disease at a late stage and have a poor prognosis. The prognostic predictors reported in the literature are not unequivocal and …
article
2013
ObjectiveTo investigate whether histone deacetylase inhibitors reduce the expression of the G-protein-coupled estrogen receptor (GPER) and whether the functional inhibition of GPER by the antagonist G-15 decreases the proliferation of endom…
article
2013
article
2012
BACKGROUND: The G protein-coupled estrogen receptor (GPER) is thought to be involved in non-genomic estrogen responses as well as processes such as cell proliferation and migration. In this study, we analyzed GPER expression patterns from e…
article
2012
Mutations of the tumor-suppressor gene ARID1A result in the loss of protein expression of the BRG-associated factor 250a (BAF250a), a large subunit of transcription-regulating Human SWI/SNF complexes, which have an important role in the con…
other
2011
BACKGROUND/AIMS: Endometriosis is a benign but chronic disorder associated with pelvic pain and infertility. Enhanced proliferation and reduced apoptosis susceptibility are characteristics of endometriosis. Cordycepin is a poly(A) polymeras…
article
2011
Introduction: G-protein coupled receptor 30 (GPR30) is a seven-transmembrane receptor suggested to be part of non-genomic estrogen responses that can, in contrast to the classic or genomic mode of ER action, occur rapidly within minutes. GP…
article
2011
ObjectiveTo investigate whether the histone deacetylase (HDAC) inhibitor romidepsin down-regulates VEGF (vascular endothelial growth factor) gene expression and abrogates VEGF protein secretion in human epithelial endometriotic cells.Design…
other
2010
Romidepsin inhibited HDAC activity, produced acetylation of the histone proteins, up-regulated p21, and down-regulated cyclins B1 and D1, resulting in proliferation inhibition and apoptosis activation in 11z immortalized epithelial endometr…
article
2008
Despite of several therapeutic options in the treatment of endometriosis, most of them are symptomatically oriented. Histone deacetylase-inhibitors (HDACi) are a novel class of epigenetic acting drugs that inhibit growth and induce apoptosi…