Koji Yamanoi

Abstract [Introduction]Recent studies have revealed pervasive mutations in cancer-related genes within many normal tissues, including the endometrium. Endometriosis-associated ovarian cancer (EAOC) is hypothesized to arise from endometrioti…

Ovarian clear cell carcinoma (CCC) is an aggressive subtype of ovarian cancer that is resistant to conventional chemotherapy, resulting in poor prognosis. CCC develops from endometriosis, which exposes tumor cells to a hypoxic microenvironm…

[Introduction] Recent studies have revealed pervasive mutations affecting cancer-related genes in many normal tissues, including the endometrium, suggesting their role in cancer development. Endometriosis-associated ovarian cancer (EAOC) is…

Adenosarcoma is a mixed epithelial and mesenchymal neoplasm composed of a malignant mesenchymal component and a benign Müllerian glandular component. Although the endometrium is the most common primary site, adenosarcoma can also occur in t…

Cervical endometriosis is a rare benign condition characterized by ectopic endometrial glands and stroma within the cervix. Its clinical and imaging features resemble those of cervical adenocarcinoma, making preoperative diagnosis difficult…

A well-differentiated endometrioid carcinoma at the site of extra-uterine/ovarian endometriosis complicates the differentiation between an uncommon metastatic pattern from a corpus cancer and a synchronous primary tumor originating from adj…

OBJECTIVE: Endometriosis is associated with various symptoms, but their severity varies from case to case. In this study, we investigated the reality of symptoms presented by patients with clinically early-stage endometriosis-associated ova…

Primary peritoneal cancer has characteristics similar to high-grade serous carcinomas of ovarian and fallopian tube origin. However, the relationship between endometriosis and primary peritoneal cancer is not well understood. This study foc…

Abstract Introduction: The epithelial cells of the endometrium undergo rapid proliferation and shedding each month under the influence of estrogen and progesterone. Recent studies have demonstrated pervasive driver mutations in the endometr…

Clear cell carcinoma (CCC) of the ovary exhibits a unique morphology and clinically malignant behavior. The eosinophilic cytoplasm includes abundant glycogen. Although the growth is slow, the prognosis is poor owing to resistance to convent…

Polypoid endometriosis (PE) is a rare distinctive variant of endometriosis with morphological features resembling malignant tumors. Although a surgical procedure is usually performed for the treatment and diagnosis of PE, fertility preserva…

In an attempt to clarify the clinical characteristics of synchronous primary endometrial and ovarian cancer (SPC), we reviewed the clinicopathological features of 13 cases treated in the Department of Gynecology and Obstetrics at Kyoto Univ…