Chu TY

No ORCID on file · 7 papers in corpus · active 2022-2025

Study types

  • article 2

Condition tags

  • endometriosis 1
article 2025
Ovulation: A consequence of acute inflammation cultivated by E2-induced reactive oxygen species and triggered by progesterone withdrawal
Tzu chi medical journal ·doi:10.4103/tcmj.tcmj_127_25

Ovulation is a complex biological process essential for female fertility, driven by the luteinizing hormone (LH) surge and involving a cascade of molecular events that lead to follicular rupture and oocyte release. This process shares chara…

2025
Ovulation releases G-CSF to induce peritoneal neutrophil influx and netosis, facilitating peritoneal seeding of high-grade serous carcinoma.
Neoplasia (New York, N.Y.) ·doi:10.1016/j.neo.2025.101236

IntroductionHigh-grade serous ovarian cancer (HGSC), the most lethal subtype of epithelial ovarian cancer (EOC), often originates from serous tubal intraepithelial carcinoma (STIC) and is typically diagnosed at advanced stages. However, the…

article 2025
Ovulatory follicular fluid promotes the clonogenicity and invasion of ectopic and eutopic endometrial cells
Tzu chi medical journal ·doi:10.4103/tcmj.tcmj_90_25

OBJECTIVES: Endometriosis is a chronic, estrogen-dependent disorder characterized by the ectopic growth of endometrial-like tissue. Despite its significant impact on fertility and quality of life, the pathogenesis of endometriosis remains p…

2025
Topological Distribution of the Sex Hormone Receptor Expressions Highlights the Importance of Stromal ERα and Epithelial PR in Malignant Transformation of the Uterine Cervix.
International journal of molecular sciences ·doi:10.3390/ijms26094418

To investigate the changes of ERα and PRs in the epithelium and stroma of normal and neoplastic uterine cervix. Two pathologists independently scored the expression levels of ERα, PR(A+B), and PRB in the stroma and epithelium of normal, cer…

2024
Diagnostics and Therapy for Malignant Tumors.
Biomedicines ·doi:10.3390/biomedicines12122659

Malignant tumors remain one of the most significant global health challenges and contribute to high mortality rates across various cancer types. The complex nature of these tumors requires multifaceted diagnostic and therapeutic approaches.…

2024
Epidermal growth factor receptor ligands enriched in follicular fluid exosomes promote oncogenesis of fallopian tube epithelial cells.
Cancer cell international ·doi:10.1186/s12935-024-03614-9

BackgroundIncessant ovulation is the main etiologic factor of ovarian high-grade serous carcinomas (HGSC), which mostly originate from the fallopian tube epithelium (FTE). Receptor tyrosine kinase (RTK) ligands essential for follicle develo…

2022
Endometrial Cancer Detection Using a Cervical DNA Methylation Assay (MPap) in Women with Abnormal Uterine Bleeding: A Multicenter Hospital-Based Validation Study.
Cancers ·doi:10.3390/cancers14174343

BackgroundWe describe a DNA methylation assay, named MPap test, using cervical scraping as an alternative technique for endometrial cancer detection.MethodsA multicenter hospital-based, two-stage validation study was conducted to validate t…