Lacy M Alexander

Endometriosis is a systemic inflammatory disease known to increase the risk of cardiovascular disease. The inducible form of cyclooxygenase (COX), COX-2, is an inflammatory enzyme upregulated in endometriosis (Endo) with COX metabolites hav…

Cardiovascular disease (CVD) risk is elevated in women with endometriosis (ENDO). Because estrogen is cardioprotective in some women, this CVD risk might be exacerbated by common ENDO treatments that suppress estrogen. The purpose of this s…

BACKGROUND: Endometriosis is a risk factor for cardiovascular disease. COX (Cyclooxygenase) is upregulated in endometriotic lesions, potentially exaggerating pressor reflexes, a major risk factor for adverse cardiovascular events. The purpo…

Women with endometriosis are at increased risk of cardiovascular disease and demonstrate endothelial dysfunction. The gold standard for diagnosis of endometriosis is through operative laparoscopy with surgical excision and histopathologic i…

Women with endometriosis, an inflammatory disease, are at increased risk of cardiovascular disease and demonstrate impaired microvascular endothelial function, characterized by reduced nitric oxide (NO)-mediated vasodilation. In some clinic…

Purpose: Endometriosis is characterized by the presence of endometrium-like tissue outside the uterine cavity. This estrogen-dependent disease is associated with systemic inflammation and increased risk of cardiovascular disease. In primate…

Cardiovascular disease (CVD) is the leading cause of death in women. Endometriosis, an estrogen-dependent systemic inflammatory disease, and hot flashes during the menopausal transition are both female-specific risk factors for CVD. Bazedox…

PURPOSE OF REVIEW: Endometriosis is a chronic, often debilitating, disease which is typically managed with surgery and hormonal medications. However, many patients feel they lack agency when managing endometriosis symptoms. The purpose of t…

Cardiovascular disease risk is elevated in women with endometriosis and may be exacerbated by treatments that suppress estrogen. The purpose of this study was to determine the effects of acute estrogen suppression on endothelial function in…

PURPOSE: Endometriosis is an estrogen-dependent gynecological disorder associated with impaired endothelial function and elevated cardiovascular disease risk. The mechanisms underpinning these impairments are unclear; however, systemic infl…

Purpose: Endometriosis is an estrogen-dependent gynecological disorder associated with systemic inflammation and arterial stiffness, which may negatively modulate shear stress patterns to promote a pro-atherogenic state, and thus contribute…

INTRODUCTION: Endometriosis is associated with systemic inflammation and increased risk of cardiovascular disease (CVD). Endothelial dysfunction is one of the first manifestations of CVD but is unexplored in women with endometriosis. HMG-Co…