Nina S. Stachenfeld

Purpose: Endometriosis is characterized by the presence of endometrium-like tissue outside the uterine cavity. This estrogen-dependent disease is associated with systemic inflammation and increased risk of cardiovascular disease. In primate…

Cardiovascular disease (CVD) is the leading cause of death in women. Endometriosis, an estrogen-dependent systemic inflammatory disease, and hot flashes during the menopausal transition are both female-specific risk factors for CVD. Bazedox…

In cardiovascular research, sex and gender have not typically been considered in research design and reporting until recently. This has resulted in clinical research findings from which not only all women, but also gender-diverse individual…

Cardiovascular disease risk is elevated in women with endometriosis and may be exacerbated by treatments that suppress estrogen. The purpose of this study was to determine the effects of acute estrogen suppression on endothelial function in…

PURPOSE: Endometriosis is an estrogen-dependent gynecological disorder associated with impaired endothelial function and elevated cardiovascular disease risk. The mechanisms underpinning these impairments are unclear; however, systemic infl…

Purpose: Endometriosis is an estrogen-dependent gynecological disorder associated with systemic inflammation and arterial stiffness, which may negatively modulate shear stress patterns to promote a pro-atherogenic state, and thus contribute…

BackgroundEpidemiologic studies have demonstrated an association between endometriosis and the subsequent development of cardiovascular disease. The direct effect of endometriosis on the progression of atherosclerotic, if any, has not been …

INTRODUCTION: Endometriosis is associated with systemic inflammation and increased risk of cardiovascular disease (CVD). Endothelial dysfunction is one of the first manifestations of CVD but is unexplored in women with endometriosis. HMG-Co…

Bazedoxifene (BZA) paired with conjugated estrogens (CE) is the first tissue selective estrogen receptor complex (TSEC) approved by the United States Food and Drug Administration for the treatment of menopausal symptoms. Clinical trials in …

BACKGROUND: Endometriosis is a gynecologic disorder affecting 6-10% of reproductive-aged women. First-line therapies are progestin-based regimens; however, failure rates are high, often requiring alternative hormonal agents, each with unfav…