Auni C. Williams

Endometriosis is a systemic inflammatory disease known to increase the risk of cardiovascular disease. The inducible form of cyclooxygenase (COX), COX-2, is an inflammatory enzyme upregulated in endometriosis (Endo) with COX metabolites hav…

The purpose of this study was to determine if COX activity modulates mechanisms of platelet aggregation and neurovascular control in patients with endometriosis. We hypothesized that women with endometriosis (Endo) would demonstrate augment…

The purpose of this study was to determine if COX activity modulates mechanisms of platelet aggregation and neurovascular control in patients with endometriosis. We hypothesized that women with endometriosis (Endo) would demonstrate augment…

Intradermal microdialysis, combined with laser-Doppler flowmetry and local heating, is commonly used to investigate mechanisms of endothelial function and dysfunction in the cutaneous microcirculation. Local perfusion of acetylcholine (ACh)…

BACKGROUND: Endometriosis is a risk factor for cardiovascular disease. COX (Cyclooxygenase) is upregulated in endometriotic lesions, potentially exaggerating pressor reflexes, a major risk factor for adverse cardiovascular events. The purpo…

Women with endometriosis are at increased risk of cardiovascular disease and demonstrate endothelial dysfunction. The gold standard for diagnosis of endometriosis is through operative laparoscopy with surgical excision and histopathologic i…

Women with endometriosis, an inflammatory disease, are at increased risk of cardiovascular disease and demonstrate impaired microvascular endothelial function, characterized by reduced nitric oxide (NO)-mediated vasodilation. In some clinic…

Purpose: Endometriosis is characterized by the presence of endometrium-like tissue outside the uterine cavity. This estrogen-dependent disease is associated with systemic inflammation and increased risk of cardiovascular disease. In primate…

Cardiovascular disease (CVD) is the leading cause of death in women. Endometriosis, an estrogen-dependent systemic inflammatory disease, and hot flashes during the menopausal transition are both female-specific risk factors for CVD. Bazedox…

PURPOSE: Endometriosis is an estrogen-dependent gynecological disorder associated with impaired endothelial function and elevated cardiovascular disease risk. The mechanisms underpinning these impairments are unclear; however, systemic infl…

Purpose: Endometriosis is an estrogen-dependent gynecological disorder associated with systemic inflammation and arterial stiffness, which may negatively modulate shear stress patterns to promote a pro-atherogenic state, and thus contribute…