Attenuated Cyclooxygenase-Mediated Vasodilation in Cutaneous Microvasculature with No Difference in Platelet Aggregation in Women with Endometriosis, supplemental data

The purpose of this study was to determine if COX activity modulates mechanisms of platelet aggregation and neurovascular control in patients with endometriosis. We hypothesized that women with endometriosis (Endo) would demonstrate augmented platelet aggregation and anodal current-induced vasodilation (a method of inducing COX-mediated vasodilation) compared with similarly aged healthy control women (HC), and that this difference would be mediated, at least in part, by COX activity. In a randomized, placebo-controlled design, 12 Endo and 9 HC participants underwent an anodal current-induced vasodilation protocol following placebo or aspirin (650 mg). Whole blood samples were taken for aggregation characteristics to be determined with impedance aggregometry analysis. These supplemental data show aggregation characteristics normalized to platelet count (Fig 1 placebo and 2 aspirin) and simple linear regressions between cutaneous vascular conductance to anodal stimulation and platelet count, PGE2, and TxB2 expression.