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BACKGROUND: Adenomyosis diagnosis and classification relies primarily on magnetic resonance imaging or pathological examination. Liquid biopsy has been widely applied in oncology but remains underexplored for adenomyosis. We aimed to identi…

BackgroundTo investigate the long-term systemic effects of tubal sterilisation using the silver clip technique, a commonly used yet understudied permanent contraceptive method, by evaluating its impact on inflammatory responses and coagulat…

Primary infertility affects 15% of couples worldwide, yet many genetic causes remain unknown. Through whole-exome sequencing of a woman with primary infertility and repeated embryo implantation failure, we identified a novel homozygous fram…

OBJECTIVE: To address the need for more objective and reproducible preoperative diagnosis of deep infiltrating endometriosis (DIE), this study aimed to develop and validate a weighted ensemble machine learning (ML) model using multimodal ma…

BackgroundOvarian cancer is a lethal gynecological malignancy, with ~70% of patients diagnosed at advanced stages (5-year survival <30%) due to suboptimal early detection tools. Current modalities [e.g., carbohydrate antigen 125 (CA125), im…

ObjectiveTo investigate the relationship between serum progesterone (P) on the day of embryo transfer (ET) and pregnancy outcomes in patients classified as POSEIDON Group 1.MethodsThis retrospective cohort study was conducted at the Reprodu…

Bisphenol A (BPA), an endocrine-disrupting chemical frequently detected in follicular fluid (FF), has been implicated in ovarian reserve dysfunction. However, data on the presence of its structural analogues within ovarian follicles remain …

Uterine rupture is a rare but life-threatening obstetric emergency, with most cases occurring during late pregnancy or labor, particularly in patients with a history of uterine surgery. This report presents an exceptionally rare case of spo…

BackgroundVaricocoele is a common cause of male infertility, affecting spermatogenesis through increased testicular temperature, venous stasis, and oxidative stress. Microsurgical subinguinal varicocelectomy improves semen quality, whereas …

ObjectiveTo identify core acupoint prescription patterns for primary dysmenorrhea (PD) using data mining and to generate hypothesis-level mechanistic insight through network-based analysis.MethodsNine Chinese and English databases were sear…

[This corrects the article DOI: 10.3389/fendo.2025.1735567.].

BackgroundSexually transmitted infections (STIs) contribute to female infertility by causing pelvic inflammatory disease (PID) and fallopian tube damage. Utilizing the Global Burden of Disease (GBD) database, we aim to comprehensively evalu…

Endometriosis is a prevalent gynecological disorder associated with chronic low-grade inflammation, yet diagnosis is often delayed because symptoms are non-specific and definitive confirmation typically relies on invasive procedures. Compos…

BACKGROUND: Endometriosis (EMs) is a chronic enigmatic gynecological disorder which pathogenesis have not been fully elucidated. Exosomes have been proven to participate in endometriosis. However, the role of exosomes in the pathogenesis of…

BackgroundSyndrome differentiation in Traditional Chinese Medicine (TCM) is pivotal to clinical practice and dictates the efficacy of medicinal treatments. However, precision diagnostic models for TCM syndromes, constructed from biomarkers …

Endometriosis (EMs) affects the physical and mental health of a wide range of women of childbearing age. Exploring specific diagnostic targets and screening potential therapeutic drugs will help early diagnosis and improve prognosis. The di…

To explore the value of the ovarian-adnexal reporting and data system (O-RADS) combined with tumor markers, risk of ovarian malignancy algorithm (ROMA) in the differential diagnosis of benign and malignant ovarian-adnexal tumors. A total of…

Endometriosis is a common gynecological disease with high recurrence rates after surgery and the lesions keep unlimited proliferative capacity. The effect of garcinol on cell proliferation has not been investigated in endometriosis. Herein,…

ObjectiveThe study systematically examines the long-term trends in the global burden of Polycystic ovary syndrome (PCOS) across 204 countries and territories, with a specific focus on comparing pre-pandemic (1990-2019) and post-pandemic (20…

BACKGROUND: Pregnant women, as well as patients with endometriosis and some ovarian tumors, may experience a state of high estrogen levels. However, the role of high estrogen in platelet function and thrombosis remains controversial, which …

BACKGROUND: Expulsion of the levonorgestrel-releasing intrauterine system (LNG-IUS) limits its effectiveness in adenomyosis management, particularly in patients with anatomical risk factors. This study aimed to assess the feasibility and sh…

BackgroundThe ovary is a vital and dynamic reproductive organ. Ovarian tissue cryopreservation (OTC) plays a vital role in preserving female fertility. However, the cellular subtypes most susceptible to cryoinjury and the molecular mechanis…

Gynecological diseases represent a persistent global health burden. According to a WHO report, the global incidence of gynecological diseases exceeds 65%. Furthermore, over 90% of women suffer from gynecological issues to varying degrees. T…