David T. Baird

article 2012

Umbilical endometriosis in a woman with bicornuate uterus.

Skinmed

A 39-year-old woman presented for evaluation of a tender nodule on the umbilicus that had been present for 6 months. She stated that it had slowly been increasing in size and would occasionally open up and crust over with dried blood. Physi…

article 2007

Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium

·doi:10.1093/molehr/gam021

In women, a single dose of the antiprogestin mifepristone (RU486) in the secretory phase rapidly renders the endometrium unreceptive and is followed by endometrial breakdown and menstruation within 72 h. This model provides a system to iden…

review 2006

Regulation of human endometrial function: mechanisms relevant to uterine bleeding

Reproductive biology and endocrinology : RB&E ·doi:10.1186/1477-7827-4-s1-s5

This review focuses on the complex events that occur in the endometrium after progesterone is withdrawn (or blocked) and menstrual bleeding ensues. A detailed understanding of these local mechanisms will enhance our knowledge of disturbed e…

article 2003

Effect of long-term treatment with low-dose mifepristone on the endometrium

·doi:10.1093/humrep/deg022

BACKGROUND: Mifepristone in low daily doses has contraceptive potential by inhibiting ovulation and menstruation. Because follicular development is maintained, the endometrium is exposed to estrogen for prolonged periods unopposed by proges…

article 2002

Daily Low-Dose Mifepristone Has Contraceptive Potential by Suppressing Ovulation and Menstruation: A Double-Blind Randomized Control Trial of 2 and 5 mg per Day for 120 Days

·doi:10.1210/jcem.87.1.8140

Daily administration of progesterone (P) antagonists to women inhibits ovulation and disrupts endometrial function. In this double-blind randomized trial, we have explored the contraceptive potential of two doses of the P antagonist mifepri…

article 2000

Clinical Uses of Antiprogestogens

·doi:10.1177/1071557600007001s13

article 2000

Progesterone Withdrawal Up-Regulates Vascular Endothelial Growth Factor Receptor Type 2 in the Superficial Zone Stroma of the Human and Macaque Endometrium: Potential Relevance to Menstruation*

·doi:10.1210/jcem.85.9.6769

Several reports indicate that vascular endothelial growth factor (VEGF) expression is increased in endometrial glands and stroma during the menstrual phase in the human endometrium. Here we report that VEGF receptor type 2 (KDR), normally e…

review 1996

Prostaglandins and menstruation

·doi:10.1016/s0301-2115(96)02568-7

article 1990

The effects of the antiprogestin mifepristone, in vivo, and progesterone in vitro on prolactin production by the human decidua in early pregnancy

·doi:10.1093/oxfordjournals.humrep.a137158

This study investigated the regulatory effect of progesterone on decidual prolactin (dPRL) production during early human pregnancy (6-7 weeks). Patients (n = 7) were treated with the antiprogestin-mifepristone (RU 486; 600 mg single oral do…

article 1989

TAMOXIFEN PROLONGS LUTEAL PHASE IN PREMENOPAUSAL WOMEN BUT HAS NO EFFECT ON THE SIZE OF UTERINE FIBROIDS

·doi:10.1111/j.1365-2265.1989.tb01257.x

Tamoxifen (20 mg per day) was administered for at least 3 months to six premenopausal women with uterine fibromyomata. In all the women there was an increased variability in the length of the menstrual and ovarian cycle associated with a si…

article 1988

The effects of clomiphene citrate on the histology of human endometrium in regularly cycling women undergoing in vitro fertilization

·doi:10.1016/s0015-0282(16)59719-2

article 1987

Endometrial prostaglandins in women with abnormal menstrual bleeding

·doi:10.1016/0262-1746(87)90014-x

article 1987

The effects of danazol mefanamic acid, norethistherone and a progesterone-impragnated coil on endometrial prostaglandin concentrations in women with monorrhagia

·doi:10.1016/0090-6980(87)90267-x

article 1984

The relationship between menstrual blood loss and prostaglandin production in the human: Evidence for increased availability of arachidonic acid in women suffering from menorrhagia

·doi:10.1016/0262-1746(84)90087-8

article 1981

PROSTAGLANDIN SYNTHESIS IN THE ENDOMETRIUM OF WOMEN WITH OVULAR DYSFUNCTIONAL UTERINE BLEEDING

·doi:10.1111/j.1471-0528.1981.tb01009.x

The endogenous concentrations of prostaglandins F2 alpha (PGF 2 alpha) and E (PGE) were measured during the luteal phase of the menstrual cycle in the endometrium from 14 women with unexplained menorrhagia (measured menstrual blood loss in …

article 1978

HYPOTHALAMIC-PITUITARY-OVARIAN FUNCTION IN PERIMENOPAUSAL WOMEN

·doi:10.1097/00006254-197802000-00021

Van Look, Paul F. A.; Lothian, Helen; Hunter, William M.; Michie, Eileen A.; Baird, David T. Author Information

article 1974

Blood Production and Ovarian Secretion Rates of Estradiol-17β and Estrone in Women with Dysfunctional Uterine Bleeding

·doi:10.1210/jcem-39-3-564

The dynamics of estrogen secretion and production were studied using isotope dilution techniques combined with direct sampling of ovarian venous blood and follicular fluid in 10 women with a clinical history of anovulatory dysfunctional ute…

article 1973

ENDOMETRIAL CYSTIC GLANDULAR HYPERPLASIA IN ADOLESCENT GIRLS

·doi:10.1097/00006254-197306000-00020

Summary The occurrence of cystic glandular hyperplasia of the endometrium in adolescent girls has been reviewed. This condition has been diagnosed much less frequently in the South-Eastern Region of Scotland than in previously reported ser…

article 1972

ENDOMETRIAL CYSTIC GLANDULAR HYPERPLASIA IN ADOLESCENT GIRLS

·doi:10.1111/j.1471-0528.1972.tb11879.x

Summary The occurrence of cystic glandular hyperplasia of the endometrium in adolescent girls has been reviewed. This condition has been diagnosed much less frequently in the South‐Eastern Region of Scotland than in previously reported seri…

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