ENDOMETRIAL CYSTIC GLANDULAR HYPERPLASIA IN ADOLESCENT GIRLS

Summary The occurrence of cystic glandular hyperplasia of the endometrium in adolescent girls has been reviewed. This condition has been diagnosed much less frequently in the South-Eastern Region of Scotland than in previously reported series. Only 5.3 cases per year were diagnosed in a population of 1 100 000 in a ten-year period. This represented 4.0 per cent of all cases of abnormal uterine bleeding requiring curettage in adolescent girls in the region, and 1.9 per cent of cases of cystic glandular hyperplasia from all age groups. Mild hyperplastic changes were found almost as frequently as the more classical “Swiss-cheese” cystic glandular hyperplasia. Patients showing more marked hyperplastic changes had a worse prognosis than those who only showed mild changes, in particular a high incidence of persistent menstrual abnormalities, repeated curettage, repeated hormone therapy, primary infertility and possible polycystic ovarian disease. The implications of the finding of cystic glandular hyperplasia in adolescent girls have been discussed.