Arisa Takeuchi

article 2025

DNA DOUBLE-STRAND BREAKS (DDSBS) OF PRIMORDIAL FOLLICLES TRIGGERS ENDOMETRIOSIS-INDUCED OVARIAN RESERVE REDUCTION AND ITS INHIBITION BY MELATONIN ADMINISTRATION

Fertility and Sterility ·doi:10.1016/j.fertnstert.2025.07.168

preprint 2023

The Long-term Impact of Post-Operative Oral Contraceptive Recommendations After Laparoscopic Cystectomy of Endometrioma on the Incidence of Endometrioma Recurrence and Ovarian Cancer Development

·doi:10.21203/rs.3.rs-2834252/v1

Abstract Background Previous studies have shown the ovarian carcinoma after laparscopic cystectomy of endometrioma arises through the recurrence of endometrioma. Then it can be assumed that reduction of ovarian endometrioma recurrence throu…

article 2022

Establishment of a novel mouse model of adenomyosis suitable for longitudinal and quantitative analysis and perinatal outcome studies

Scientific reports ·doi:10.1038/s41598-022-22413-8

The purpose of this study was to establish a novel mouse model of adenomyosis suitable for longitudinal and quantitative analyses and perinatal outcome studies. Using a 30 G needle, the entire uterine wall of one horn was mechanically punct…

preprint 2022

Establishment of a novel mouse model of adenomyosis suitable for longitudinal and quantitative analysis and perinatal outcome studies

·doi:10.21203/rs.3.rs-1332354/v2

preprint 2022

Establishment of a Novel Mouse Model of Adenomyosis Suitable for Longitudinal and Quantitative Analysis and Perinatal Outcome Studies

·doi:10.21203/rs.3.rs-1332354/v1

other 2022

Impact of Chronic Exposure to Endometriosis on Perinatal Outcomes: Establishment of a Mouse Model

Biomedicines ·doi:10.3390/biomedicines10102627

The purpose of this study was to establish a new mouse model of endometriosis that mimics real-world women's health problems, in which women continue to be affected by endometriosis long before they wish to become pregnant, and to evaluate …

other 2021

The roles of polymorphonuclear myeloid-derived suppressor cells in endometriosis

Journal of reproductive immunology ·doi:10.1016/j.jri.2021.103371

OBJECTIVES: This study aimed to determine the systemic and local proportions, focal localization, and characteristics of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) in endometriosis. STUDY DESIGN: Peripheral blood and pe…

article 2021

The roles of polymorphonuclear myeloid-derived suppressor cells in endometriosis patients

·doi:10.1016/j.jri.2021.103388

other 2020

IFITM1 is a Novel, Highly Sensitive Marker for Endometriotic Stromal Cells in Ovarian and Extragenital Endometriosis

Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-020-00189-4

When the presence of endometriotic lesions are not evident by hematoxylin and eosin staining, CD10 is used to highlight and confirm the presence of endometriotic stroma. However, CD10 is not specific only to the endometrial stroma but is al…

article 2020

PAX8: A Highly Sensitive Marker for the Glands in Extragenital Endometriosis

Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-020-00186-7

article 2020

The effects of tokishakuyakusan, a traditional Japanese medicine (kampo), ferulic acid and paeoniflorin, on human endometriotic stromal cells and peritoneal macrophages

Journal of reproductive immunology ·doi:10.1016/j.jri.2020.103104

article 2020

Use of selective PGE2 receptor antagonists on human endometriotic stromal cells and peritoneal macrophages

Molecular human reproduction ·doi:10.1093/molehr/gaaa077

Non-hormonal therapeutic strategies for endometriosis are needed. The aim of this study was to characterize the effects of prostaglandin (PG)E2 receptor inhibitors to explore their potential as novel therapeutic strategies for endometriosis…

article 2019

Activation of endoplasmic reticulum stress mediates oxidative stress–induced apoptosis of granulosa cells in ovaries affected by endometrioma

Molecular human reproduction ·doi:10.1093/molehr/gaz066

Endometriosis exerts detrimental effects on ovarian physiology and compromises follicular health. Granulosa cells from patients with endometriosis are characterized by increased apoptosis, as well as high oxidative stress. Endoplasmic retic…

article 2019

Endometriosis Triggers Excessive Activation of Primordial Follicles via PI3K-PTEN-Akt-Foxo3 Pathway

The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2019-00281

CONTEXT: The ovarian reserve is reduced in patients with endometriosis. We hypothesize that the phosphatidylinositol 3-kinase (PI3K)-phosphatase and tensin homolog deleted on chromosome 10 (PTEN) Akt-Forkhead box O (Foxo3) pathway is involv…

article 2019

IFITM1 is a Novel, Highly Sensitive Marker for Endometriotic Stromal Cells in Ovarian and Extragenital Endometriosis

Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719119831782

article 2019

PAX8: A Highly Sensitive Marker for the Glands in Extragenital Endometriosis

Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719119828095

article 2018

Expression of Nerve Injury-Induced Protein1 (Ninj1) in Endometriosis

Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719118806395

review 2018

Involvement of immune cells in the pathogenesis of endometriosis

Journal of Obstetrics and Gynaecology Research ·doi:10.1111/jog.13559

Endometriosis is characterized by the implantation and growth of endometriotic tissues outside the uterus. It is widely accepted the theory that endometriosis is caused by the implantation of endometrial tissue from retrograde menstruation;…

article 2017

Resveratrol suppresses inflammatory responses of peritoneal macrophages in endometriosis

article 2017

The activation of PI3K/Akt/mTOR pathway is associated with the activation of primordial follicles in ovaries affected with endometrioma

article 2016

Dienogest reduces nerve growth factor expression in human adenomyosis

·doi:10.1016/j.jri.2016.04.016

article 2016

Dienogest reduces nerve growth factor expression in human adenomyosis

·doi:10.1016/j.jri.2016.04.184

article 2016

Dienogest reduces proliferation, NGF expression and nerve fiber density in human adenomyosis