Ian S. Fraser
No ORCID on file
· 139 papers in corpus
other
2011
At this juncture, clinical management, education for medical providers, and the design and interpretation of clinical trials have been hampered by the absence of a consensus system for nomenclature for the description of symptoms as well as…
other
2011
Malcolm G. Munro, MD, FRCS(c), FACOG Hilary O.D. Critchley, BSc (Hons), MB ChB (Hons), MD, FRCOG, FRANZCOG, FFSRH, FMedSci Ian S. Fraser, AO, MD, BSc (Hons), FRANZCOG, CREI, FRCOG, FFFP (Hon), DUa Ian Fraser is a Professor of Reproductive M…
observational
2011
There is increasing interest in the structure of the microvascular environment in human endometrium because of the recognition of the complexity and functional importance of this tissue. Endometrial microcirculatory networks and their relat…
2010
diagnostic-accuracy
2010
background: Diagnosis of endometriosis currently requires a laparoscopy and this need probably contributes to the considerable average delay in diagnosis. We have reported the presence of nerve fibres in the functional layer of endometrium …
2010
other
2010
The more that one looks at the condition endometriosis, the more one realises that it is a unique and complex condition exhibiting a bizarre range of deviations from normal endometrial and myometrial physiology, and presenting with a challe…
other
2010
Ovarian endometriomas (n = 29) were innervated by mainly sympathetic and sensory fibers. These fibers may be involved in the generation of pain symptoms.
review
2010
Non-contraceptive health benefits are now recognized as an important aspect of the overall impact of all hormonal contraceptives. The levonorgestrel-releasing intrauterine systems (LNG IUS) are particularly effective at producing a number o…
lab-animal
2010
Introduction: Endometriosis, defined as the growth of endometrial tissue outside \nthe uterine cavity is a common gynaecological disorder affecting 10-15% \nof women in their reproductive years. It is a major clinical problem causing in- \n…
2010
Background: Endometriosis is a benign gynecological condition, associated with a dysfunctional immune response that facilitates progression of peritoneal lesions. Specific immune cells are hypothes...
2010
Background: Endometriosis is a benign gynecological condition, associated with a dysfunctional immune response that facilitates progression of peritoneal lesions. Specific immune cells are hypothesized to be recruited to peritoneal endometr…
observational
2010
BACKGROUND: Endometriosis is an inflammatory condition, associated with highly dysregulated immune response at both uterine and peritoneal levels. Surprisingly, Foxp3+ regulatory T-cells, which control and suppress a range of immune respons…
2010
observational
2010
Purpose Endometriosis is a common disease, associated with persistent and severe symptoms including infertility and pain, however, pathogenesis remains poorly understood. It has been hypothesized that fragments of viable endometrial tissue …
observational
2009
OBJECTIVE: To explore the association between the symptom of abdominal bloating and the diagnosis of endometriosis. METHODS: Twenty-six patients with endometriosis diagnosed by laparoscopy and 25 women without endometriosis were recruited …
observational
2009
BACKGROUND: Immune alterations may be involved in the pathogenesis and progression of endometriosis. Dendritic cells (DCs) are potent antigen presenting cells that are highly involved in the initiation of the immune response. The aim of thi…
review
2009
Abnormal uterine bleeding is a highly prevalent condition that can cause significant morbidity. This article summarizes the literature on the burden of illness, including an assessment of prevalence, its effect on the quality of life of suf…
other
2009
STUDY OBJECTIVE: To investigate the extent and types of innervation of endometriotic lesions in various regions of the bowel. DESIGN: Retrospective nonrandomized immunohistochemical study (Canadian Task Force classification II-3. SETTING:…
2009
observational
2009
BACKGROUND: Endometriosis is an inflammatory condition, characterized by the presence of endometrial-like tissue outside the uterus. The immune system provides a defence mechanism in response to foreign pathogens, and macrophages play impor…
observational
2009
BACKGROUND: Endometriosis is a common gynaecological disease, but the pathogenesis of endometriosis and pathophysiological basis for endometriosis-associated painful symptoms are still uncertain. Little is known about neuroendocrine (NE) ce…
other
2008
OBJECTIVE: To investigate how progestogens and combined oral contraceptives change nerve fiber density in peritoneal endometriotic lesions and to identify the types of nerve fibers still present during hormone treatment. DESIGN: Laboratory…
lab-animal
2008
OBJECTIVE: To investigate how hormonal treatment can change nerve fiber density and to identify types of nerve fibers in endometrium and myometrium in women with endometriosis. DESIGN: Laboratory study using human tissue. SETTING: Univers…
observational
2008
BACKGROUND: Endometriosis is considered to be an inflammatory disease, and macrophages are the most numerous immune cells in endometriotic lesions. However, the mechanisms underlying the elevation of macrophages and their role in the pathog…