Differential immunohistochemical expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in cow uteri with adenomyosis during follicular phase

Lio Moreira, Eulógio Carlos Queiroz de Carvalho, Maria Clara Caldas-Bussiere, M.C. Caldas-Bussiere
Veterinary research communications · 2011 · vol. 35(5) , pp. 261–269 · doi:10.1007/s11259-011-9470-1 · PMID:21626345 · W2112580893
article OA: closed CC0 ⤵ 5 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Matrix metalloproteinase-2 (MMP-2) expression was higher in deep adenomyosis samples and generally exceeded tissue inhibitor of metalloproteinase-2 (TIMP-2) expression in most uterine structures, unlike normal or superficial adenomyosis tissues.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

The study examined immunohistochemical expression of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in uterine tissue from 32 reproductive-age cows, grouped by adenomyosis degree (superficial vs deep) and sampled during the follicular phase. Using monoclonal antibodies, staining intensity was evaluated across multiple uterine compartments, including luminal epithelium, ectopic/dystopic endometrial tissue, endometrial-myometrial border, myometrium, and myometrial vessels. MMP-2 expression was higher in deep adenomyosis across several structures, and MMP-2 generally exceeded TIMP-2 in deep cases, whereas TIMP-2 exceeded MMP-2 in normal specimens and in superficial adenomyosis during the follicular phase. This paper is centrally about endometriosis and/or adenomyosis — it directly investigates adenomyosis in bovine uteri by characterizing differential MMP-2 and TIMP-2 expression patterns.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Cattle Diseases Endometriosis Endometrium Matrix Metalloproteinase 2 Myometrium Tissue Inhibitor of Metalloproteinase-2 Animals Cattle Cattle Diseases Cattle Diseases Cattle Diseases Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Follicular Phase Immunohistochemistry

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