Effects of long-term low-dose mifepristone on reproductive function in women
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⤵ 14 in-corpus citations
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Daily low-dose mifepristone interfered with endometrial development and ovarian cyclicity in women, causing altered morphology and inconsistent bleeding patterns despite some biphasic cycles.
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Abstract
Low-dose antiprogestin administration has been proposed as a new contraceptive modality to interference with endometrial receptivity without disturbing ovarian function. The effects of 1 mg/day mifepristone for 150 days on the menstrual cycle were assessed in 21 surgically sterilized women. The aim was to study each woman for one control cycle and during months 1, 3 and 5 of treatment. Ovulation, endometrial thickness, serum oestradiol and progesterone, urinary luteinizing hormone, endometrial morphology and cervical mucus were assessed. Luteal phase progesterone concentrations were observed in 36 of the 60 treated months assessed and less frequently as treatment progressed. The bleeding pattern was regular in most biphasic cycles, while prolonged interbleeding intervals or no bleeding were associated with monophasic cycles. Altered endometrial morphology was found in all cases irrespective of the occurrence of luteal activity. Increased endometrial thickness and dilated glands were observed in 25 and 34% respectively of the monophasic cycles. Mifepristone, 1 mg/day, interferes with endometrial development while allowing the occurrence of biphasic ovarian cycles and regular bleeding. However, it also prevents ovarian cyclicity in a high proportion of treated months, and this is associated with increased endometrial growth in some women, which may be of concern.
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Cited by (14)
- Mifepristone increases AQP1 mRNA expression, angiogenesis, and cell permeability through the ERK MAPK pathway 2022
- Physiology of the Endometrium and Regulation of Menstruation 2020
- Mifepristone: where do we come from and where are we going? 2010
- Progesterone receptor modulators and the endometrium: changes and consequences† 2007
- Progesterone receptor antagonists and selective progesterone receptor modulators: proven and potential clinical applications 2007
- Inhibition of Proliferation of Endometrial Stromal Cells by Trichostatin A, RU486, CDB-2914, N-Acetylcysteine, and ICI 182780 2006
- The effects of 1-month administration of asoprisnil (J867), a selective progesterone receptor modulator, in healthy premenopausal women 2005
- Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications 2005
- Effects of Hormones 2005
- Effect of long-term treatment with low-dose mifepristone on the endometrium 2003
- Progesterone antagonists and progesterone receptor modulators: an overview 2003
- Daily Low-Dose Mifepristone Has Contraceptive Potential by Suppressing Ovulation and Menstruation: A Double-Blind Randomized Control Trial of 2 and 5 mg per Day for 120 Days 2002
- Progesterone receptor modulators and progesterone antagonists in women's health 2000
- Mechanism of action and clinical effects of antiprogestins on the non-pregnant uterus 1998
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