Cyclical gonadotrophin and progesterone secretion in women with minimal endometriosis
Observational
OA: closed
CC0
⤵ 14 in-corpus citations
AI-generated summary
Women with minimal endometriosis and infertility often exhibit luteal phase defects including delayed or reduced progesterone secretion and abnormal luteinizing hormone patterns.
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Abstract
Concentrations of LH, FSH, oestradiol (E) and progesterone (P) were measured in serum of 12 women with minimal endometriosis and otherwise unexplained infertility. Values were compared with those on corresponding days relative to the pre-ovulatory LH peak (Day 0) in six fertile women. Three women exhibited cycle profiles of LH, FSH, E and P indistinguishable from those in the control group. In the remaining nine women cycle profiles for FSH and follicular phase profiles for LH were normal but eight exhibited a delay in P secretion and reduced total P output. LH concentrations were elevated during the early luteal phase in five subjects, two of whom had a second LH surge. These data suggest that luteal dysfunction and abnormal secretory patterns for LH may be contributory to infertility associated with endometriosis.
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Cited by (14)
- Identifying Mechanisms of Endometriosis-Associated Reduced Fecundity in a Rat Model: Novel Insights toward Understanding Human Infertility 2020
- Dose-Dependent Decreased Fertility in Response to the Burden of Endometriosis in a Murine Model 2019
- The genetics and biochemistry of endometriosis 2013
- Elevated peritoneal fluid TNF-α incites ovarian early growth response factor 1 expression and downstream protease mediators: a correlation with ovulatory dysfunction in endometriosis 2013
- Cellular and molecular basis for endometriosis-associated infertility 2012
- Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis 2007
- Physiopathological aspects of corpus luteum defect in infertile patients with mild/minimal endometriosis 2003
- Follicular and luteal phase salivary progesterone profiles in women with endometriosis and infertility 1994
- Pituitary-ovarian function in women with minimal or mild endometriosis and otherwise unexplained infertility 1992
- Follicular development in spontaneous and stimulated cycles in women with minimal-mild endometriosis 1991
- The impact of previous danazol treatment on circulating hormone levels, follicular development and oocyte maturity in minimal-mild endometriosis 1991
- Endometriosis as a cause of infertility 1989
- Minimal/mild endometriosis and infertility. A review 1989
- Successful treatment of asymptomatic endometriosis: does it benefit infertile women? 1987
Source provenance
- europepmc
- last seen: 2026-10-09T06:09:53.026058+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:24:17.697085+00:00
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