Dynamic weight bearing as a non-reflexive method for the measurement of abdominal pain in mice

Alexis Laux‐Biehlmann, A Laux-Biehlmann, J Boyken, Boyken J, Janina Boyken, Henrik Dahllöf, Dahllöf H, H Dahllöf, N Schmidt, Nicole Schmidt, T M Zollner, Thomas M. Zollner, Zollner TM, Jens Nagel, J Nagel
European journal of pain (London, England) · 2015 · vol. 20(5) , pp. 742–752 · doi:10.1002/ejp.800 · PMID:26684879 · W2277444342
Lab / animal OA: closed CC0 ⤵ 5 in-corpus citations
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This study utilized the dynamic weight bearing system to assess abdominal pain in a mouse model of peritonitis, finding that increased weight on front paws correlated with inflammatory mediators and was reversed by pain medication.

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Abstract

BACKGROUND: Chronic pelvic pain (CPP) is a high burden for patients and society. It affects 15-24% of women in reproductive age and is an area of high unmet medical need. CPP can be caused by a wide range of visceral diseases such as abdominal infections, gastrointestinal or gynaecological diseases like endometriosis. Despite the high medical need for this condition, pharmacological approaches are hampered by the limited number of available methods for the behavioural evaluation of pain in inflammation-driven animal models of pelvic pain. METHODS: The dynamic weight bearing (DWB) system was used for the evaluation of spontaneous behaviour changes in the zymosan-induced peritonitis mouse model. Inflammatory mediator levels were evaluated in peritoneal lavage and their correlation with the behavioural endpoints was assessed. We evaluated the effect on behavioural endpoints of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib and the Nav 1.8 blocker A-803467. RESULTS: The presence of a relief posture, characterized by a significantly increased weight distribution towards the front paws, was observed following intraperitoneal injection of zymosan. A positive correlation was detected between PGE2 levels in the peritoneal lavage and DWB endpoints. In addition, zymosan-induced weight bearing changes were reverted by celecoxib and A-803467. CONCLUSIONS: This study described for the first time the use of DWB as a non-subjective and non-reflexive method for the evaluation of inflammatory-driven abdominal pain in a mouse model.

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Condition tags

chronic_pelvic_painendometriosis

MeSH descriptors

Abdominal Pain Behavior, Animal Cyclooxygenase 2 Inhibitors Pain Measurement Sodium Channel Blockers Weight-Bearing Weight-Bearing Abdominal Pain Abdominal Pain Abdominal Pain Abdominal Pain Aniline Compounds Aniline Compounds Aniline Compounds Animals Animals Behavior, Animal Behavior, Animal Celecoxib Celecoxib

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References (58)

Cited by (6)

Source provenance

europepmc
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openalex
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pubmed
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License: CC0 · commercial use OK