Knockdown of E-cadherin expression of endometrial epithelial cells may activate Wnt/β-catenin pathway in vitro

Xiaoxiong Zhu, Yan Li, Rong‐Miao Zhou, Rongmiao Zhou, Na Wang, Shan Kang
Archives of gynecology and obstetrics · 2017 · vol. 297(1) , pp. 117–123 · doi:10.1007/s00404-017-4560-0 · PMID:29018948 · W2764257947
article OA: closed CC0 ⤵ 14 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

Knockdown of E-cadherin in endometrial epithelial cells increased cell migration and invasion, and upregulated β-catenin, cyclin D1, and c-myc protein levels.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This paper examined whether knocking down E-cadherin (CDH1) in cultured human endometrial epithelial cells affects cell behavior and Wnt/β-catenin signaling. Endometrial epithelial cells were isolated from normal endometrium of fertile women and transfected with CDH1-targeting small hairpin RNA, with an empty vector as control; migration and invasion were measured by Transwell assays and β-catenin pathway activity was assessed by qRT-PCR and western blot. CDH1 knockdown increased migration and invasion and upregulated β-catenin, cyclin D1, and c-myc, leading the authors to conclude that E-cadherin downregulation may activate the Wnt/β-catenin pathway in endometrial cells, although the study is limited to in vitro experiments. This paper is centrally about endometriosis — it specifically tests a proposed mechanism that E-cadherin downregulation can activate Wnt/β-catenin signaling in endometrial epithelial cells, which the authors link to endometriosis occurrence.

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Condition tags

endometriosis

MeSH descriptors

beta Catenin Cadherins Endometriosis Endometrium Epithelial Cells Wnt Signaling Pathway Adult Antigens, CD beta Catenin Cadherins Endometriosis Endometriosis Endometrium Endometrium Epithelial Cells Female Humans Middle Aged Wnt Signaling Pathway

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