Rectal endometriosis mimicking solitary rectal ulcer syndrome.

Daya D, D Daya, O'Connell G, G O'Connell, Graeme O’Connell, DeNardi F, F DeNardi, Franco DeNardi
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 1995 · vol. 8(6) , pp. 599–602 · PMID:8532690 · W2409590619
article OA: closed CC0 ⤵ 10 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-27 ⓘ

This report details a case where rectal endometriosis mimicked solitary rectal ulcer syndrome and required multiple biopsies, aided by immunohistochemistry, to differentiate from colitis cystica profunda.

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Abstract

We report a unique case of rectal endometriosis mimicking solitary rectal ulcer syndrome. Several rectal biopsies were performed before the correct diagnosis of rectal endometriosis was made. The lesion had striking histologic features resembling colitis cystica profunda. The presence of two types of glands, i.e., colonic glands with marked depletion of mucin and endometrial glands, were readily apparent on immunohistochemical stain using anticarcinoembryonic antigen showing positive cytoplasmic stain for colonic glands but negative for endometrial glands. However, the distinction between colonic and endometrial glands was very difficult on hematoxylin-and-eosin-stained slides. Endometrial stroma was identified only in the sixth biopsy specimen. Although rare, rectal endometriosis should be considered in the differential diagnosis of solitary rectal ulcer syndrome.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Rectal Diseases Rectum Adult Biopsy Carcinoembryonic Antigen Carcinoembryonic Antigen Colon Colon Diagnosis, Differential Diagnostic Errors Endometriosis Endometrium Endometrium Female Humans Rectal Diseases Rectum Syndrome Ulcer

Citation neighborhood

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Cited by (10)

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europepmc
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License: CC0 · commercial use OK