Efficacy of luteal supplementation of vaginal sildenafil and oral estrogen on pregnancy rate following IVF-ET in women with a history of thin endometria: A pilot study
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Concomitant administration of vaginal sildenafil and oral estrogen alongside progesterone luteal support increased clinical pregnancy rates two-fold in women with thin endometria undergoing IVF.
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Abstract
Objective: The several strategies for unexplained thin endometrium are under debate. We evaluated the effect of concomitant administration of vaginal sildenafil and oral estrogen in women with a thin endometrium undergoing in vitro fertilization (IVF). Methods: Forty-eight women showing thin endometrium less than 8 mm at the time of embryo transfer were randomly assigned to the study (n=21) and control group (n=27) in their subsequent IVF cycles. Routine luteal support was made by vaginal micronized progesterone 600 mg/day. In the study group, oral estradiol valerate 4 mg/day + vaginal sildenafil 25 mg/day was administered from the day of embryo transfer. Results: The clinical pregnancy rate was two-fold higher in the study group, although it was not statistically significant (47.6% vs. 25.9%, P=0.209). Conclusion: Our study supports that luteal administration of vaginal sildenafil and oral estrogen has modest beneficial impact on the uterine receptivity.
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Cites (3)
- Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium 2009
- Pathophysiologic features of “thin” endometrium 2008
- Extended estrogen administration for women with thin endometrium in frozen-thawed in-vitro fertilization programs 2006
Cited by (2)
References (14)
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Cited by (2)
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