Sildenafil Supplementation for Women Undergoing Infertility Treatments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Loris Marin, Alessandra Andrisani, Luciana Bordin, Francesco Dessole, Marco Noventa, Amerigo Vitagliano, Giampiero Capobianco, Guido Ambrosini
In: Journal of Clinical Medicine · 2021 · vol. 10(19) , pp. 4346 · doi:10.3390/jcm10194346 · PMID:34640363 · W3202931953
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This meta-analysis found Sildenafil improved endometrial thickness and pregnancy rates in women undergoing ovulation induction, but not in fresh or frozen embryo transfers, except for a higher chemical pregnancy rate.

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Abstract

The aim of this systematic review and meta-analysis is to summarize data on the effectiveness of Sildenafil supplementation for women undergoing assisted reproduction techniques. This meta-analysis of randomized controlled trials (RCTs) evaluates the effects of Sildenafil administration during infertility treatments compared with a control group in infertile women. Outcomes evaluated were endometrial thickness (ETh) and the clinical pregnancy rate (CPR). The chemical pregnancy rate (ChPR) was also evaluated. Pooled results were expressed as the risk ratio (RR) or mean differences (MD) with a 95% confidence interval (95% CI). Women undergoing ovulation induction who received Sildenafil showed higher ETh and a higher CPR in comparison to controls. In this group, both the ETh and ChPR resulted in significantly higher values only with delayed start administration. Women undergoing fresh or frozen embryo transfer who received Sildenafil showed no significant advantages regarding ETh and CPR in comparison to controls. In this group, we found a significantly higher ChPR in women receiving Sildenafil. A subgroup analysis revealed significant advantages regarding ETh with oral administration for women undergoing fresh or frozen embryo transfer. Sildenafil therapy appears to improve endometrial thickness and pregnancy rate in women undergoing timed intercourses but it resulted not effective in IUI and IVF treatments. Further RCTs with rigorous methodology are still mandatory.

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infertility

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SciLite annotations

chemicals 82
sildenafil sildenafil sildenafil sildenafil sildenafil sildenafil sildenafil sildenafil diethylcarbamazine citrate sildenafil sildenafil sildenafil sildenafil sildenafil sildenafil sildenafil sildenafil sildenafil tadalafil sildenafil estradiol clomiphene diethylcarbamazine citrate clomiphene diethylcarbamazine citrate letrozole progesterone sildenafil sildenafil estradiol progesterone estradiol estradiol progesterone progesterone sildenafil sildenafil sildenafil sildenafil progesterone sildenafil estrogen sildenafil sildenafil sildenafil sildenafil estradiol clopidogrel pentoxifylline tadalafil sildenafil sildenafil sildenafil sildenafil sildenafil sildenafil sildenafil sildenafil estrogen sildenafil +22 more
organisms 7
noordeloos 2009062 noordeloos 2009062 noordeloos 2009062 noordeloos 2009062 noordeloos 2009062 noordeloos 2009062 noordeloos 2009062

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