Tadalafil for Endometrial Growth in Clomiphene Citrate stimulated cycles in an IUI programma: A pilot study.

Daniel H Méndez Lozano, M V Lenero, R González, Juliano Brum Scheffer, Miguel González, Y Barron, R Frydman
In: Facts, views & vision in ObGyn · 2015 · vol. 7(4) , pp. 231–237 · PMID:27729968 · W2558322545
article OA: green CC0 ⤵ 1 in-corpus citation
🔓 Open OA copy View on OpenAlex View on PubMed
⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Tadalafil improved endometrial growth and decreased uterine artery resistance index in patients undergoing clomiphene stimulation for IUI, without affecting pulsatility index or estradiol levels.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

AIM OF THE STUDY: The objective of this study was to assess the impact of tadalafil on endometrial growth, the uterine artery pulsatility index (PI) and the uterine artery resistance index (RI) in patients under clomiphene ovarian stimulation for intrauterine insemination (IUI). METHODS: This randomized crossover study included 30 patients with a normal endometrium over 53 cycles, and 46 of those cycles in 23 patients were included in the analysis. In group A the patients were under 100 mg clomiphene daily for five days (2-6) and 5 mg tadalafil daily for 7 days (4-10). For Group B (control) the patients only received clomiphene. Measurements of the endometrium, PI, RI and estradiol determinations were taken on cycle days 4, 8 and 10. RESULTS: We observed a better endometrial growth in Group A compared to Group B: 7.5 ± 2.1 mm vs 5.5 ± 1.2 mm, P < 0.0002 and 8.9 ± 1.8 mm vs 6.3 ± 1.8 mm, P < 0.0002 on days 8 and 10, respectively. Additionally, a progressive decrease in the RI was observed in Group A but not in Group B from day 8 (0.77 ± 0.15 vs 0.85 ± 0.18, P = 0.059) to day 10 (0.74 ± 0.20 vs 0.87 ± 0.14, P < 0.017). However, no differences were observed in PI or serum estradiol between Group A and Group B. CONCLUSION: The use of tadalafil improved endometrial growth in patients under clomiphene ovarian stimulation with no significant effect on the uterine artery Pulsatility Index and serum estradiol.

My notes (saved in your browser only)

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (3)

Cited by (1)

References (24)

Cited by (1)

SciLite annotations

chemicals 57
tadalafil clomiphene diethylcarbamazine citrate tadalafil clomiphene tadalafil clomiphene estradiol estradiol clomiphene estradiol tadalafil clomiphene diethylcarbamazine citrate sildenafil tadalafil clomiphene tadalafil clomiphene estradiol clomiphene diethylcarbamazine citrate tadalafil clomiphene diethylcarbamazine citrate tadalafil estradiol progesterone estradiol estradiol tadalafil clomiphene tadalafil diethylcarbamazine citrate estradiol tadalafil sildenafil clomiphene diethylcarbamazine citrate tadalafil clomiphene diethylcarbamazine citrate tadalafil sildenafil tadalafil sildenafil tadalafil clomiphene tadalafil estradiol tadalafil clomiphene diethylcarbamazine citrate tadalafil tadalafil clomiphene diethylcarbamazine citrate

Source provenance

openalex
last seen: 2026-05-10T11:13:13.260719+00:00
scilite
last seen: 2026-05-18T04:57:49.680383+00:00
License: CC0 · commercial use OK