Downregulation of lncRNA LINC01465 predicts ovarian endometriosis and its prognosis

Summary The well-known impact of ovarian endometriosis on female quality of life and the established role of lncRNA LINC01465 in ovarian cancer pathogenesis have been extensively documented; however, the relationship between LINC01465 and ovarian endometriosis is still not clear. This study seeks to explore the potential involvement of LINC01465 in the disease. The study analyzed a sample of 80 endometriosis patients and 80 healthy women. The expression of LINC01465 was measured in ectopic and eutopic endometrial tissues through RT-qPCR. The diagnostic potential of serum LINC01465 levels was evaluated using ROC curve analysis, and the patients were followed up for 3 years after treatment to monitor recurrence. The results revealed that the expression of LINC01465 was significantly lower in ectopic endometrial tissues in comparison to paired eutopic tissues for most of the patients. No correlation was found between the patient’s age or lifestyle and serum LINC01465 levels. After treatment, the serum LINC01465 level increased, and patients who experienced recurrence had significantly lower levels compared to those who did not. In conclusion, the study findings suggest that the downregulation of LINC01465 plays a role in the pathogenesis of ovarian endometriosis and may serve as a diagnostic and prognostic biomarker for the disease. Similar content being viewed by others References Králíčková M, Laganà AS, Ghezzi F, Vetvicka V. Endometriosis and risk of ovarian cancer: what do we know? Arch Gynecol Obstet. 2020;301:1–10. Mo X, Zeng Y. The relationship between ovarian endometriosis and clinical pregnancy and abortion rate based on logistic regression model. Saudi J Biol Sci. 2020;27:561–6. Streuli I, Gaitzsch H, Wenger JM, Petignat P. Endometriosis after menopause: physiopathology and management of an uncommon condition. Climacteric. 2017;20:138–43. Falcone T, Flyckt R. Clinical Management of Endometriosis. 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Nurs Made Incred Easy. 2019;17:26–33. Koga K, Takamura M, Fujii T, Osuga Y. Prevention of the recurrence of symptom and lesions after conservative surgery for endometriosis. Fertil Steril. 2015;104:793–801. Funding We thank the financial support from the Innovative R&D project of Hunan Provincial Development and Reform Commission (No. 37). Author information Authors and Affiliations Contributions YS conducted this study and wrote this manuscript. RH, XH, SW, SC, GL, MO analyzed and interpreted the patient data. HG designed the study. All authors read and approved the final manuscript. Corresponding author Ethics declarations Conflict of interest Y. Song, R. Huang, X. Hu, S. Wu, S. Chen, G. Liu, M. Ou and H. Guo declare that they have no competing interests. Ethical standards All procedures performed in studies involving human participants or on human tissue were in accordance with the ethical standards of the institutional and/or national research committee and with the 1975 Helsinki declaration and its later amendments or comparable ethical standards. Approval was obtained from the Ethics Committee of Changsha Maternal and Child Health Care Hospital. Written informed consent was obtained from all individual patients included in the study. Additional information Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Availability of data and material The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. Rights and permissions About this article Cite this article Song, Y., Huang, R., Hu, X. et al. Downregulation of lncRNA LINC01465 predicts ovarian endometriosis and its prognosis. Wien Klin Wochenschr 136, 163–168 (2024). https://doi.org/10.1007/s00508-023-02219-y Received: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s00508-023-02219-y