Fertility Outcomes – Reducing Ovarian Damage During Endometriosis Surgery

In: Endometriosis in Adolescents · 2020 · pp. 393–403 · doi:10.1007/978-3-030-52984-0_21 · W3102766864
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This chapter reviews the pathophysiology, evaluation, and prevalence of ovarian reserve decrease after endometrioma surgery and discusses innovative techniques to reduce surgical damage.

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This chapter reviews ovarian reserve changes and fertility outcomes after surgical treatment of ovarian endometriomas, focusing on how different cyst excision techniques may reduce damage to healthy ovarian tissue. It summarizes the rationale for cystectomy as recommended by ESHRE to manage endometriomas while noting that surgery can cause postsurgical reduction in the number and quality of follicles. It presents pathophysiology, evaluation methods for decreased ovarian reserve, and multiple innovative surgical approaches, while explicitly stating that simple drainage alone is associated with a high recurrence rate and is therefore not recommended. This paper is centrally about endometriosis — specifically, how to reduce ovarian damage and preserve ovarian reserve during endometrioma surgery in adolescents and other patients.

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Abstract

Ovarian endometriomas are cysts on or within the ovarian parenchyma that contain chocolate-like fluid. Ovarian endometriomas are a typical manifestation of the disease, and their prevalence is between 17% and 44% of patients with endometriosis (Jenkins et al., Obstet Gynecol 67(3):335–338, 1986; Redwine, Fertil Steril 72(2):310–315, 1999; Busacca and Vignali, Curr Opin Obstet Gynecol 15:321–326, 2003). According to the European Society of Human Reproduction and Embryology (ESHRE) guidelines, ovarian cystectomy is the preferred modality of treatment of endometriomas, so as to prevent recurrence of endometriosis-associated symptoms and in order to increase the spontaneous pregnancy rate (Dunselman et al., Hum Reprod 29(3):400–412, 2014). However, the guidelines suggested a possible postsurgical reduction in the number and quality of the follicles in the ovaries, i.e., ovarian reserve reduction. Indeed, the most common side effect of cystectomy is damage to healthy ovarian tissue. Reduction of the deleterious effects of surgery on ovarian reserve is a major concern to all reproductive surgeons. The issue of reducing the deleterious effect of surgery on ovarian reserve is many times over important in adolescent girls; therefore, it is given a place in this textbook. In this chapter, we will review the pathophysiology, evaluation, and prevalence of the decrease in ovarian reserve after surgical treatment of endometriomas and the recommended surgical technique for cyst excision and ablation. Several surgical innovative techniques have been developed in recent years aiming to reduce ovarian damage, and these techniques will be presented and discussed. Simple drainage of the endometrioma alone has been shown to have a high rate of recurrence of symptoms (Donnez et al., Fertil Steril 62(1):63–66, 1994; Vercellini et al., J Reprod Med 37(7):577–580, 1992); therefore, this procedure is not recommended and will not be discussed. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

References

Jenkins S, Olive DL, Haney AF. Endometriosis: pathogenetic implications of the anatomic distribution. Obstet Gynecol. 1986;67(3):335–8. Redwine DB. Ovarian endometriosis: a marker for more extensive pelvic and intestinal disease. Fertil Steril. 1999;72(2):310–5. Busacca M, Vignali M. Ovarian endometriosis: from pathogenesis to surgical treatment. Curr Opin Obstet Gynecol. 2003;15:321–6. Dunselman GA, Vermeulen N, Becker C, Calhaz-Jorge C, D’Hooghe T, Bie B, et al. ESHRE guideline. Hum Reprod. 2014;29(3):400–12. Donnez J, Nisolle M, Gillerot S, Anaf V, Clerckx-Braun F, Casanas-Roux F. Ovarian endometrial cysts: the role of gonadotropin-releasing hormone agonist and/or drainage. Fertil Steril [Internet]. 1994 July [cited 2018 Dec 20];62(1):63–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8005305. Vercellini P, Vendola N, Bocciolone L, Colombo A, Rognoni MT, Bolis G. Laparoscopic aspiration of ovarian endometriomas. Effect with postoperative gonadotropin releasing hormone agonist treatment. J Reprod Med [Internet]. 1992 July [cited 2018 Dec 20];37(7):577–80. Available from: http://www.ncbi.nlm.nih.gov/pubmed/1387905. Nezhat C, Paka BE, Nezhat C, Nezhat F. Video-assisted laparoscopic treatment of endometriosis. In: Nezhat C, Nezhat F, Nezhat C, editors. Nezhat’s video-assisted and robotic-assisted laparoscopy and hysteroscopy. New York: Cambridge University Press; 2013. Muzii L, Bellati F, Bianchi A, Palaia I, Manci N, Zullo MA, et al. Laparoscopic stripping of endometriomas: a randomized trial on different surgical techniques. Part II: pathological results. [cited 2018 Oct 21]. Available from: https://academic.oup.com/humrep/article-abstract/20/7/1987/2356535. Nezhat F, Nezhat C, Allan CJ, Metzger DA, Sears DL. Clinical and histologic classification of endometriomas. Implications for a mechanism of pathogenesis. J Reprod Med. 1992;37:771–6. Nezhat C, Nezhat F, Nezhat C, Seidman DS. Classification of endometriosis. Improving the classification of endometriotic ovarian cysts. Hum Reprod. 1994;9(12):2212–3. Reich H, Abrao MS. Post-surgical ovarian failure after laparoscopic excision of bilateral endometriomas: Is this rare problem preventable? Am J Obstet Gynecol [Internet]. 2006 Aug 1 [cited 2018 Nov 16];195(2):339–40. Available from: https://www.sciencedirect.com/science/article/pii/S0002937806004753?via%3Dihub. Nezhat C, Paka BE, Nezhat C, Nezhat F. Video-assisted laparoscopic treatment of endometriosis. In: Nezhat C, Nezhat F, Nezhat C, editors. Nezhat’s video-assisted and robotic-assisted laparoscopy and hysteroscopy. New York: Cambridge University Press; 2013. p. 277. Vercellini P, Chapron C, De Giorgi O, Consonni D, Frontino G, Crosignani PG. Coagulation or excision of ovarian endometriomas? Am J Obstet Gynecol [Internet]. 2003 Mar [cited 2018 Dec 20];188(3):606–10. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12634628. Testing and interpreting measures of ovarian reserve: a committee opinion. [cited 2018 Dec 28]. Available from: https://doi.org/10.1016/j.fertnstert.2014.12.093. Leone U, Maggiore R, Scala C, Venturini PL, Remorgida V, Ferrero S. Endometriotic ovarian cysts do not negatively affect the rate of spontaneous ovulation. [cited 2018 Oct 21]. Available from: https://academic.oup.com/humrep/article-abstract/30/2/299/726881. Benschop L, Farquhar C, van der Poel N, Heineman MJ. Interventions for women with endometrioma prior to assisted reproductive technology. Cochrane Database Syst Rev [Internet]. 2010. Available from: http://doi.wiley.com/10.1002/14651858.CD008571.pub2. Flyckt R, Soto E, Falcone T. Endometriomas and assisted reproductive technology. Semin Reprod Med. 2013;31(2):164–72. Dilek U, Pata O, Tataroglu C, Aban M, Dilek S. Excision of endometriotic cyst wall may cause loss of functional ovarian tissue. Fertil Steril. 2006;85(3):758–60. Goodman LR, Goldberg JM, Flyckt RL, Gupta M, Harwalker J, Falcone T. Effect of surgery on ovarian reserve in women with endometriomas, endometriosis and controls. Am J Obstet Gynecol. 2016;215:589.e1–6. Muzii L, Tucci C Di, Feliciantonio M Di, Marchetti C, Perniola G, Panici PB. The effect of surgery for endometrioma on ovarian reserve evaluated by antral follicle count: a systematic review and meta-analysis. Adv Access Publ August [Internet]. 2014 [cited 2018 Oct 21];29(10):2190–8. Available from: https://academic.oup.com/humrep/article-abstract/29/10/2190/648644. Raffi F, Metwally M, Amer S. The impact of excision of ovarian endometrioma on ovarian reserve: a systematic review and meta-analysis. 2012 [cited 2018 Oct 21]. Available from: https://academic.oup.com/jcem/article-abstract/97/9/3146/2536935. Goodman LR, Goldberg JM, Flyckt RL, Gupta M, Harwalker J, Falcone T. Effect of surgery on ovarian reserve in women with endometriomas, endometriosis and controls. 2016 [cited 2018 Oct 21]. Available from: https://doi.org/10.1016/j.ajog.2016.05.029. Ozaki R, Kumakiri J, Tinelli A, Grimbizis GF, Kitade M, Takeda S. Evaluation of factors predicting diminished ovarian reserve before and after laparoscopic cystectomy for ovarian endometriomas: a prospective cohort study. 2016 [cited 2018 Oct 21]. Available from: https://ovarianresearch.biomedcentral.com/track/pdf/10.1186/s13048-016-0241-z. Muzii L, Achilli C, Lecce F, Bianchi A, Franceschetti S, Marchetti C, et al. Second surgery for recurrent endometriomas is more harmful to healthy ovarian tissue and ovarian reserve than first surgery. Fertil Steril [Internet]. 2015 Mar [cited 2018 Oct 21];103(3):738–43. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0015028214025266. Nargund G, Cheng WC, Parsons J. The impact of ovarian cystectomy on ovarian response to stimulation during in-vitro fertilization cycles. Hum Reprod. 1996;11(1):81–3. Somigliana E, Ragni G, Benedetti F, Borroni R, Vegetti W, Crosignani PG. Does laparoscopic excision of endometriotic ovarian cysts significantly affect ovarian reserve? Insights from IVF cycles. Hum Reprod. 2003;18(11):2450–3. Shah DK, Mejia RB, Lebovic DI. Effect of surgery for endometrioma on ovarian function. J Minim Invasive Gynecol [Internet]. 2013;21(2):203–9. Available from: https://doi.org/10.1016/j.jmig.2013.09.012. Busacca M, Riparini J, Somigliana E, Oggioni G, Izzo S, Vignali M, et al. Postsurgical ovarian failure after laparoscopic excision of bilateral endometriomas. Am J Obstet Gynecol. 2006;195(2):421–5. Coccia ME, Rizzello F, Mariani G, Bulletti C, Palagiano A, Scarselli G. Ovarian surgery for bilateral endometriomas influences age at menopause. Hum Reprod. 2011;26(11):3000–7. Roman H, Auber M, Mokdad C, Martin C, Diguet A, Marpeau L, et al. Ovarian endometrioma ablation using plasma energy versus cystectomy: A step toward better preservation of the ovarian parenchyma in women wishing to conceive. Fertil Steril [Internet]. 2011 Dec [cited 2018 Dec 15];96(6):1396–400. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22019124. Mircea O, Puscasiu L, Resch B, Lucas J, Collinet P, von Theobald P, et al. Fertility outcomes after ablation using plasma energy versus cystectomy in infertile women with ovarian endometrioma: a multicentric comparative study. J Minim Invasive Gynecol [Internet]. 2016 Nov [cited 2018 Dec 15];23(7):1138–45. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27553184. Donnez J, Lousse JC, Jadoul P, Donnez O, Squifflet J. Laparoscopic management of endometriomas using a combined technique of excisional (cystectomy) and ablative surgery. Fertil Steril. 2010;94(1):28–32. https://doi.org/10.1016/j.fertnstert.2009.02.065. Epub 2009 Apr 9. Zaitoun MM, Zaitoun M, El Behery MM. Comparing long term impact on ovarian reserve between laparoscopic ovarian cystectomy and open laparotomy for ovarian endometrioma. J Ovarian Res [Internet]. 2013 Nov 2 [cited 2019 Jan 19];6(1):76. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24180348. Mohamed ML, Nouh AA, El-Behery MM, Mansour SAE-A. Effect on ovarian reserve of laparoscopic bipolar electrocoagulation versus laparotomic hemostatic sutures during unilateral ovarian cystectomy. Int J Gynecol Obstet [Internet]. 2011 Jul 1 [cited 2019 Jan 19];114(1):69–72. Available from: http://doi.wiley.com/10.1016/j.ijgo.2011.01.010. Peters A, Rindos NB, Lee T. Hemostasis during ovarian cystectomy: systematic review of the impact of suturing versus surgical energy on ovarian function. J Minim Invasive Gynecol. 2017;24:235–46. Author information Authors and Affiliations Editor information Editors and Affiliations Rights and permissions Copyright information © 2020 Springer Nature Switzerland AG About this chapter Cite this chapter Mashiach, R., Admon, D., Mashiach, S. (2020). Fertility Outcomes – Reducing Ovarian Damage During Endometriosis Surgery. In: Nezhat, C.H. (eds) Endometriosis in Adolescents. Springer, Cham. https://doi.org/10.1007/978-3-030-52984-0_21 Download citation DOI: https://doi.org/10.1007/978-3-030-52984-0_21 Published: Publisher Name: Springer, Cham Print ISBN: 978-3-030-52983-3 Online ISBN: 978-3-030-52984-0 eBook Packages: MedicineMedicine (R0)

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