Development of hepatocellular carcinoma after long-term immunosuppressive therapy including danazol in a dog

Kosuke Kobayashi, Takako SHIMOKAWA MIYAMA, Kazuhito ITAMOTO, Shunsuke Noguchi, Kenji Baba, Takuya Mizuno, Masaru Okuda
In: Journal of Veterinary Medical Science · 2016 · vol. 78(10) , pp. 1611–1614 · doi:10.1292/jvms.16-0019 · PMID:27320967 · PMC5095632 · W2434836310
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This case report describes the development of hepatocellular carcinoma in a dog treated with long-term immunosuppressive therapy including danazol for immune-mediated anemia.

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Abstract

A 2-year-old female beagle was referred to our hospital for evaluation of anemia. Laboratory tests, including bone marrow cytology, revealed non-regenerative immune-mediated anemia (NRIMA). Although initial immunosuppressive multi-drug therapy was not effective, additional administration of danazol was successful in treating the anemia. However, hepatocellular carcinoma (HCC) developed about 20 months after the administration of danazol. In humans, several cases of development of HCC after the administration of danazol have been reported. The present report describes a case of HCC development in a dog after chronic administration of danazol in addition to other immunosuppressive drugs.
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Internal Medicine Development of hepatocellular carcinoma after long-term immunosuppressive therapy including danazol in a dog 2016 Volume 78 Issue 10 Pages 1611-1614 Details Abstract A 2-year-old female beagle was referred to our hospital for evaluation of anemia. Laboratory tests, including bone marrow cytology, revealed non-regenerative immune-mediated anemia (NRIMA). Although initial immunosuppressive multi-drug therapy was not effective, additional administration of danazol was successful in treating the anemia. However, hepatocellular carcinoma (HCC) developed about 20 months after the administration of danazol. In humans, several cases of development of HCC after the administration of danazol have been reported. The present report describes a case of HCC development in a dog after chronic administration of danazol in addition to other immunosuppressive drugs. © 2016 by the Japanese Society of Veterinary Science この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja Favorites & Alerts Recently viewed articles

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