Chronic antiprogestin therapy produces a stable atrophic endometrium with decreased fibroblast growth factor: a 1-year primate study on contraception and amenorrhea

D. R. Grow, Daniel R. Grow, M T Reece, J G Hsiu, Jeng G. Hsiu, L A Adams, L Adams, Patricia M. Newcomb, P M Newcomb, Robert F. Williams, R F Williams, Gary D. Hodgen, G. D. Hodgen
Fertility and sterility · 1998 · vol. 69(5) , pp. 936–943 · doi:10.1016/s0015-0282(98)00029-6 · PMID:9591506 · W2061581560
Lab / animal OA: closed CC0 ⤵ 11 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

This 1-year primate study found that chronic antiprogestin therapy induces a stable atrophic endometrium, characterized by reduced fibroblast growth factor levels, offering potential insights into contraception and amenorrhea.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To describe the efficacy of mifepristone in the prevention of menstrual bleeding and ovulation, with similar observations in comparison groups. DESIGN: Prospective experimental study. Thirty-two cynomolgus monkeys were divided equally into four treatment groups (n = 8). Treatment lasted for 1 year. INTERVENTION(S): Group I received GnRH-agonist (GnRH-a) and in-sequence mifepristone, group II received mifepristone only, group III received GnRH-a only, and group IV received vehicle control. MAIN OUTCOME MEASURE(S): Serum estradiol and progesterone, menstrual bleeding, endometrial thickness, and endometrial expression of basic fibroblast growth factor (bFGF) as determined by immunohistochemistry. RESULT(S): Weekly progesterone determinations showed that mifepristone-treated monkeys seldom ovulated (6 ovulations in 8 years), compared with the controls (100 ovulations in 8 years), while maintaining early to midfollicular levels of circulating serum estradiol. The GnRH-a-only group also rarely ovulated, but was chronically and severely hypoestrogenic. The mifepristone-only group showed scant menstrual bleeding (5 days in 8 years) as compared with the menstrual frequency in control animals (422 days in 8 years). Endometrial proliferation, as determined by biopsy, was similarly minimal for both the GnRH-a and mifepristone groups, and statistically less than in control monkeys. Both the mifepristone and GnRH-a treatments suppressed endometrial gland expression of the angiogenesis polypeptide bFGF. CONCLUSION(S): Chronic mifepristone induced anovulation along with virtual amenorrhea, which suggests the worth of this novel hormonal contraceptive.

My notes (saved in your browser only)

MeSH descriptors

Amenorrhea Endometrium Fibroblast Growth Factor 2 Hormone Antagonists Mifepristone Amenorrhea Animals Contraception Endometrium Endometrium Female Fibroblast Growth Factor 2 Hormone Antagonists Leuprolide Leuprolide Macaca fascicularis Mifepristone Ovulation Ovulation

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (25)

Cited by (10)

Source provenance

openalex
last seen: 2026-05-11T06:18:49.075943+00:00
pubmed
last seen: 2026-10-08T22:00:35.617750+00:00
License: CC0 · commercial use OK