Pathogenesis of endometriosis in adolescence: role of systemic inflammation, neoneuro- and neoangiogenesis

E.P. Khaschenko, E.Z. Allkhverdieva, E.V. Uvarovа, I.A. Salnikovа
In: Pediatric and Adolescent Reproductive Health · 2022 · vol. 18(3) , pp. 55–64 · doi:10.33029/1816-2134-2022-18-3-55-64 · W4312608358
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated the role of systemic inflammation, neoneurogenesis, and neoangiogenesis in the pathogenesis of endometriosis in adolescents.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

The paper reviews current concepts of endometriosis pathogenesis in adolescence, emphasizing systemic inflammation and the roles of neo-neurogenesis and neoangiogenesis, drawing together implantational, metaplastic (celomic), immunologic, disontogenetic, and hematogenous/lymphogenous hypotheses. It highlights findings such as estrogen-dependent chronic inflammation, dysregulated immune responses with impaired NK-cell cytotoxicity, macrophage-driven proinflammatory cytokine production (including TNF-α and IL-1β/IL-6/IL-8), altered adhesion/invasion mechanisms (e.g., ICAM-1, E-cadherin, CD-44), and reduced macrophage phagocytic function via prostaglandin E2–mediated effects, alongside mechanisms linking estrogen exposure to angiogenesis and pain-related nerve signaling. A stated limitation is that no single pathogenic theory has been conclusively confirmed, and adolescent epidemiology is difficult to determine due to a lack of population studies. This paper is centrally about endometriosis — it focuses on adolescent endometriosis pathogenesis and the roles of systemic inflammation, neurogenesis, and angiogenesis.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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