Ser312Gly Polymorphism of the HSD17β1 Gene is not Associated with Endometriosis in Brazilian Patients

Raphaela Paulo dos Santos, CAROLINA BARBARA NOGUEIRA DE OLIVEIRA, Priscila Falagan-Lotsch, Marcelle G. Souza, Ricardo Bassil Lasmar, Luciana B. Duarte, Paula Andrea Navarro, José Mauro Granjeiro, Ivan Araújo Penna
In: Journal of Endometriosis and Pelvic Pain Disorders · 2014 · vol. 6(3) , pp. 144–149 · doi:10.5301/je.5000195 · W2002753164
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This case-control study found no significant association between the Ser312Gly polymorphism of the HSD17β1 gene and endometriosis in Brazilian women.

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Abstract

Purpose The aim of this study was to determine whether a polymorphism of the HSD17β1 gene (rs605059), involved in estrogen synthesis, is associated with endometriosis in Brazilian patients. Methods A case-control study was conducted in 231 women. All patients in the case group had a histopathological diagnosis of endometriosis. Genomic DNA was genotyped by nested-PCR, followed by digestion of the PCR product with the enzyme BstUI. Results The frequencies of the genotypes detected in the case and control groups were 22.4% GG, 52.2% AG and 25.4% AA; and 31.3% GG, 49.3% AG and 19.4% AA, respectively, with no significant difference between groups. The prevalence of the G allele was 48.5% and 56% in the case and control groups, respectively. No significant difference in genotype or allele frequency was detected between the different stages of endometriosis (p>0.05). Conclusions The results suggested that the Ser312Gly polymorphism of the HSD17β1 gene is not associated with endometriosis in Brazilian patients.

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endometriosis

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