Phthalate monoesters in association with uterine leiomyomata in Shanghai

Jing Sun, Meiru Zhang, Mei-Ru Zhang, Li-Qian Zhang, Liqian Zhang, Dong Zhao, Shuguang Li, Shu-Guang Li, Bo Chen
International journal of environmental health research · 2015 · vol. 26(3) , pp. 306–316 · doi:10.1080/09603123.2015.1111310 · PMID:26608625 · W2230113124
Observational OA: closed CC0 ⤵ 1 in-corpus citation
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

This case-control study found significantly higher urinary levels of multiple phthalate metabolites in women with uterine leiomyomata compared to controls, suggesting an association.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Phthalates are ubiquitous environmental pollutants because of the broad use of plastics. We conducted a case-control study to determine whether uterine leiomyomata were related to exposure to phthalates. Urine specimens and questionnaires were collected from 61 cases and 61 age-matched controls. Nine phthalate monoesters were determined by ultra performance liquid chromatography coupled with tandem mass spectroscopy. Cases had significantly higher levels of creatinine-adjusted mono-iso-butyl phthalate (MiBP), mono-n-butyl phthalate (MnBP), mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-oxohexyl phthalate, mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), total di(2-ethylhexyl) phthalate metabolites (∑DEHPmet), and total dibutyl phthalate metabolites (∑DBP(met)) than controls. After adjusting for potential confounders, logistic regression analyses demonstrated that leiomyomata were positively associated with MiBP, MnBP, MEHP, MEHHP, MECPP, ∑DEHP(met), and ∑DBP(met). In summary, our data support the hypothesis that uterine leiomyomata are related to phthalate exposure.

My notes (saved in your browser only)

MeSH descriptors

Environmental Exposure Environmental Pollutants Esters Leiomyoma Phthalic Acids Uterine Neoplasms Adolescent Case-Control Studies China China Environmental Monitoring Environmental Pollutants Esters Female Humans Leiomyoma Leiomyoma Phthalic Acids Uterine Neoplasms Uterine Neoplasms

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (33)

Cited by (1)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:16:50.396854+00:00
License: CC0 · commercial use OK