Gonadotropin-releasing hormone analogue plus hormone replacement therapy for the treatment of endometriosis: a randomized controlled trial
RCT
OA: closed
CC0
⤵ 15 in-corpus citations
AI-generated summary
Combined hormone replacement therapy with a GnRH analogue effectively treated endometriosis while preventing hypoestrogenic side effects like hot flashes and bone loss.
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Abstract
OBJECTIVE: The aim of this study was to determine whether or not continuous combined HRT used with GnRH-a for the treatment of endometriosis can prevent hypoestrogenic side effects associated with GnRH-a.
METHODS: Forty premenopausal women with laparoscopically proven endometriosis entered the study. The patients were randomized into two groups. Group I (n = 19) received 3.75 mg i.m. leuprolide acetate (LA) every 4 weeks for 24 weeks. Group II (n = 21) received 3.7 mg LA combined with 1.25 mg oral conjugated equine estrogen (CEE) and 5 mg oral medroxyprogesterone acetate (MA).
RESULTS: Total revised AFS score as well as total pelvic pain scores decreased significantly (P < .001) in both groups. However, a statistically significant difference of hot flushes and sweating was reported by women receiving LA + HRT as compared to those treated with LA alone (P < .001). Furthermore, the bone loss at the lumbar spine was 4.2% in group I compared to 0.9% in group II at the end of the study.
CONCLUSIONS: This study suggests that 1.25 mg CEE + 5 mg MA is effective in preventing hypoestrogenic side effects caused by GnRH-a, while the treatment of endometriosis is not impaired.
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Cited by (15)
- A systematic literature review on patient-reported outcome domains and measures in nonsurgical efficacy trials related to chronic pain associated with endometriosis: an urgent call to action 2024
- Gonadotropin-releasing hormone analogues for endometriosis 2023
- Treatment of Endometriosis with the GnRHa Deslorelin and Add-Back Estradiol and Supplementary Testosterone 2015
- Systematic review of endometriosis pain assessment: how to choose a scale? 2014
- The effects of ergot and non-ergot-derived dopamine agonists in an experimental mouse model of endometriosis 2011
- Endometriosis 2010
- Effects of hyperprolactinemia treatment with the dopamine agonist quinagolide on endometriotic lesions in patients with endometriosis-associated hyperprolactinemia 2010
- Optimal management of chronic cyclical pelvic pain: an evidence-based and pragmatic approach 2010
- Endometriosis 2007
- An open and randomized study comparing the efficacy of standard danazol and modified triptorelin regimens for postoperative disease management of moderate to severe endometriosis 2004
- One year comparison between two add-back therapies in patients treated with a GnRH agonist for symptomatic endometriosis: a randomized double-blind trial 2004
- Gonadotrophin-releasing hormone analogues for endometriosis: bone mineral density 2003
- Diagnosis and treatment of endometriosis 2003
- Extracts from the "clinical evidence". Endometriosis 2000
- Endometriosis: an overview of the disease and its treatment 2000
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- europepmc
- last seen: 2026-10-18T09:30:06.152893+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T22:00:28.864438+00:00
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