In Vitro Simulation of the Environment in the Upper Gastrointestinal Lumen After Drug Administration in the Fed State Using the TIM-1 System and Comparison With Luminal Data in Adults

Christina Pentafragka; Irena Tomaszewska; Susann Bellmann; Mans Minekus; Ronald Schilderink; Maria Vertzoni; Mark McAllister; Christos Reppas

doi:10.1016/j.xphs.2021.10.010

In Vitro Simulation of the Environment in the Upper Gastrointestinal Lumen After Drug Administration in the Fed State Using the TIM-1 System and Comparison With Luminal Data in Adults

Christina Pentafragka, Irena Tomaszewska, Susann Bellmann, Mans Minekus, Ronald Schilderink, Maria Vertzoni, Mark McAllister, Christos Reppas

In: Journal of Pharmaceutical Sciences · 2021 · vol. 111(1) , pp. 197–205 · doi:10.1016/j.xphs.2021.10.010 · PMID:34673096 · W3207710200

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This study utilized the TIM-1 system to simulate the upper gastrointestinal environment in the fed state after drug administration and compared the results with luminal data from adults.

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Disposition of two highly permeable drugs in the upper gastrointestinal lumen of healthy adults after a standard high-calorie, high-fat meal 2020

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[1] Disposition of two highly permeable drugs in the upper gastrointestinal lumen of healthy adults after a standard high-calorie, high-fat meal 2020