Disposition of two highly permeable drugs in the upper gastrointestinal lumen of healthy adults after a standard high-calorie, high-fat meal

Christina Pentafragka; Maria Vertzoni; Mira Symillides; Konstantinos Goumas; Christos Reppas

doi:10.1016/j.ejps.2020.105351

Disposition of two highly permeable drugs in the upper gastrointestinal lumen of healthy adults after a standard high-calorie, high-fat meal

Christina Pentafragka, Maria Vertzoni, Mira Symillides, Konstantinos Goumas, Christos Reppas

In: European Journal of Pharmaceutical Sciences · 2020 · vol. 149 , pp. 105351 · doi:10.1016/j.ejps.2020.105351 · PMID:32311455 · W3017161046

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This study investigated the disposition of two highly permeable drugs within the upper gastrointestinal tract of healthy adults following the ingestion of a standard high-calorie, high-fat meal.

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In Vitro Simulation of the Environment in the Upper Gastrointestinal Lumen After Drug Administration in the Fed State Using the TIM-1 System and Comparison With Luminal Data in Adults 2021

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Cited by (1)

In Vitro Simulation of the Environment in the Upper Gastrointestinal Lumen After Drug Administration in the Fed State Using the TIM-1 System and Comparison With Luminal Data in Adults 2021

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[1] Luminal Lipid Phases after Administration of a Triglyceride Solution of Danazol in the Fed State and Their Contribution to the Flux of Danazol Across Caco-2 Cell Monolayers 2012

[2] In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media 2005