Epidemiologie, Pathogenese und Diagnostik der Endometriose

Schindler Ae
2007 · vol. 17(4) , pp. 22–27 · W1601025542
article OA: green CC0 ⤵ 7 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This paper reviews the epidemiology, pathogenesis, and diagnostics of endometriosis, a common benign proliferative disease in women characterized by pelvic pain, infertility, and bleeding disorders.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

Schindler reviews epidemiology, proposed pathogenetic mechanisms, and diagnostic considerations for endometriosis, defining it as endometrial-like tissue outside the uterine cavity and distinguishing two pathologic morphological expressions: endometriosis and adenomyosis. Drawing on prior observational and theoretical work, the paper reports that exact incidence/prevalence are unknown because definitive assessment would require laparoscopy, but it summarizes prevalence estimates across clinical contexts and identifies multiple risk factors (e.g., early menarche, dysmenorrhea, nulliparity, family history, adiposity-related associations, immune factors, and environmental exposures). It argues that pathogenesis remains incompletely understood, with evidence supporting genetic and immunologic contributions, and it highlights that no single theory explains all findings, listing multiple endometriosis theories and combination concepts. This paper is centrally about endometriosis — it focuses on the epidemiology, pathogenesis, and diagnostic aspects of endometriosis and explicitly includes adenomyosis as a related pathological form.

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Abstract

Endometriose ist eine häufige sogenannte "gutartige proliferative Erkrankung" der Frau (ähnlich wie Myom, Endometriumhyperplasie und Mastopathie). Zur Erklärung der Entstehung sind verschiedene Endometriosetheorien entwickelt worden. Es bestehen zwei pathologische Ausdrucksformen: 1. Endometriose, 2. Adenomyose. Zahlreiche Risikofaktoren von Endometriose sind identifiziert worden. Die Pathogenese ist letztendlich aber noch nicht endgültig geklärt. Die Hauptsymptome der Endometriose/Adenomyose sind Unterbauchschmerzen, Sterilität und Blutungsstörungen. Aufgrund des weltweit noch bestehenden jahrelangen Zeitintervalls vom Einsetzen der Symptome bis zur Diagnose der Endometriose müssen die diagnostischen Möglichkeiten immer wieder hervorgehoben werden, denn es ist entscheidend, fortgeschrittene Stadien der Endometriose/Adenomyose möglichst zu vermeiden, um negative Auswirkungen auf die Schmerzproblematik und Konzeptionsfähigkeit zu vermeiden und die Lebensqualität optimal zu gestalten. Letztendlich scheinen eine frühe Diagnose der Endometriose/Adenomyose und eine gezielte Behandlung auch das Brustkrebsrisiko der Frau mit Endometriose zu vermindern.

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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