The gonadotropin-releasing hormone agonist leuprolide acetate induces apoptosis and suppresses cell proliferative activity in rectovaginal endometriosis

Takahiro Mizutani, Mizutani T, T Mizutani, A Sugihara, Ayako Sugihara, Sugihara A, Nakamuro K, K Nakamuro, Karo Nakamuro, Suehara N, Noriyuki Suehara, N Suehara, Nobuyuki Terada, Terada N, N Terada
American journal of obstetrics and gynecology · 1999 · vol. 181(3) , pp. 750–751 · doi:10.1016/s0002-9378(99)70523-5 · PMID:10486494 · W2090513868
Case report OA: closed CC0 ⤵ 10 in-corpus citations
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Leuprolide acetate, a gonadotropin-releasing hormone agonist, was found to induce apoptosis and suppress cell proliferation in rectovaginal endometriosis.

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Abstract

A gonadotropin-releasing hormone agonist, leuprolide acetate, was administered every 4 weeks for treatment of rectovaginal endometriosis. Degrees of apoptosis (percentage of in situ deoxyribonucleic acid 3'-end-labeled cells) and cell proliferative activity (percentage of cells with immunostaining for proliferating cell protein Ki-67) were examined in endometriotic glands of biopsy specimens taken before and during gonadotropin-releasing hormone agonist therapy. Gonadotropin-releasing hormone agonist induced apoptosis and suppressed cell proliferative activity in endometriotic glands.

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Condition tags

endometriosisbowel_endometriosis

MeSH descriptors

Apoptosis Apoptosis Cell Division Cell Division Endometriosis Leuprolide Rectal Diseases Vaginal Diseases Adult Adult Biopsy Biopsy Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (2)

Cited by (10)

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License: CC0 · commercial use OK