The gonadotropin-releasing hormone agonist leuprolide acetate induces apoptosis and suppresses cell proliferative activity in rectovaginal endometriosis

Takahiro Mizutani, Mizutani T, T Mizutani, A Sugihara, Ayako Sugihara, Sugihara A, Nakamuro K, K Nakamuro, Karo Nakamuro, Suehara N, Noriyuki Suehara, N Suehara, Nobuyuki Terada, Terada N, N Terada
American journal of obstetrics and gynecology · 1999 · vol. 181(3) , pp. 750–751 · doi:10.1016/s0002-9378(99)70523-5 · PMID:10486494 · W2090513868
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Leuprolide acetate, a gonadotropin-releasing hormone agonist, was found to induce apoptosis and suppress cell proliferation in rectovaginal endometriosis.

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Abstract

A gonadotropin-releasing hormone agonist, leuprolide acetate, was administered every 4 weeks for treatment of rectovaginal endometriosis. Degrees of apoptosis (percentage of in situ deoxyribonucleic acid 3'-end-labeled cells) and cell proliferative activity (percentage of cells with immunostaining for proliferating cell protein Ki-67) were examined in endometriotic glands of biopsy specimens taken before and during gonadotropin-releasing hormone agonist therapy. Gonadotropin-releasing hormone agonist induced apoptosis and suppressed cell proliferative activity in endometriotic glands.

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Condition tags

endometriosisbowel_endometriosis

MeSH descriptors

Apoptosis Cell Division Endometriosis Leuprolide Rectal Diseases Vaginal Diseases Adult Biopsy Endometriosis Endometriosis Endometriosis Female Humans Ki-67 Antigen Ki-67 Antigen Leuprolide Leuprolide Rectal Diseases Rectal Diseases Rectal Diseases

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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