Cystic tumor ablation with different concentrations of lauromacrogol solution in an animal model

Fei Gao, Gao F, Li H, Huikai Li, Xiuxue Feng, Feng X, Chen Du, Du C, Ke Han, Ningli Chai, Chai N, Enqiang Linghu, Linghu E
Minerva gastroenterology · 2023 · vol. 70(4) , pp. 422–429 · doi:10.23736/s2724-5985.23.03486-1 · PMID:37671940 · W4386466581
article OA: closed CC0
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This study evaluated the efficacy and safety of different lauromacrogol concentrations for cystic tumor ablation in a rat endometriosis model, finding 1%, 2%, and 3% solutions effective and safe.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

BACKGROUND: Lauromacrogol, as a sclerosing agent, can induce aseptic inflammation and fibrous tissue proliferation to achieve sclerotherapy. Lauromacrogol is widely used not only for vascular sclerotherapy but also for the treatment of different cystic tumors. To evaluate the efficacy and safety of cystic tumor ablation with different concentrations of lauromacrogol solution in a rat endometriosis model, and explore the advantages and disadvantages of this model in simulating pancreatic cystic neoplasm. METHODS: An endometriotic cyst model was established in 50 mature female Sprague-Dawley rats. After 4 weeks, successfully modeled cysts were randomly divided into four groups: group A, in which cyst were injected with normal saline; and groups B to D, in which cyst were injected with 1%, 2%, and 3% lauromacrogol solution, respectively. The rats were then fed for 4 more weeks. The abdominal cavity was opened to observe the morphology of the cyst and the degree of damage to surrounding organs. If the ablation procedure failed, the whole cyst was collected; if the ablation procedure was successful, residual scar tissue was collected. The ratio of ablated epithelial cells to the epithelial layer and the intactness of the lamina propria were observed by low- and high-power microscopy. RESULTS: After ablation, the cysts in normal saline group showed a maintained hemispherical structure, whereas those in three different concentrations of lauromacrogol solution groups showed a flat scar. The effective rate of each group was statistically different. Pairwise comparison of corrected significance levels using the Bonferroni method showed statistically a significant difference between normal saline group and 1% lauromacrogol solution group, 2% lauromacrogol solution group and 3% lauromacrogol solution group. CONCLUSIONS: According to the morphology and pathology of rat endometriotic cysts after ablation, it can be preliminarily concluded that ablation with 1%, 2%, or 3% lauromacrogol solution is an effective and safe therapeutic option. Rat endometriotic cyst model can simulate pancreatic cystic neoplasms to a certain extent.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (3)

References (28)

Source provenance

europepmc
last seen: 2026-08-25T06:10:03.373225+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-08-25T06:08:50.992859+00:00
License: CC0 · commercial use OK